Lalit Kishore and Randhir Singh
Ch. Devi Lal College of Pharmacy, India
Maharishi Markandeshwar University, India
Posters & Accepted Abstracts: J Exp Food Chem
Statement of the Problem: Reactive oxygen species, formation of AGEs and apoptosis are implicated in the pathogenesis of diabetic neuropathy. The aim of the present study was to explore the effect of Eruca sativa (Family: Brassicaceae) on thermal and mechanical hyperalgesia, allodynia, MNCV and oxidative-nitrosative stress in streptozotocin (STZ) induced experimental diabetes. Methodology: Diabetes neuropathy was induced in Wistar rats by injection of STZ (65mg/kg, i.p.) 15 min after Nicotinamide (230mg/kg, i.p.) administration. Hydro-alcohol extract of E. sativa seeds was assessed by oral administration at 100, 200 and 400mg/kg in STZ-induced diabetic rats. Thermal hyperalgesia (Eddy's hot plate and tail immersion), mechanical hyperalgesia (Randall-Selitto) and tactile allodynia (Von Frey hair tests) were evaluated in all groups of streptozotocin diabetic rats to assess the extent of neuropathy. Diabetic rats developed neuropathy which was evident from a marked hyperalgesia and allodynia; reduced MNCV associated with increased formation of AGEs and reactive oxygen/nitrogen species. Findings: Chronic treatment with E. sativa hydro-alcohol extract (100, 200 and 400mg/kg) for 30 days starting from the 60th day of STZ-induction significantly attenuated behavioral and biochemical changes associated with diabetic neuropathy. Conclusion: Present study suggested that E. sativa hydro-alcohol extract corrected the hyperglycemia and partially reversed the pain response in diabetic rats through modulation of oxidative-nitrosative stress and reduction in AGEs formation in the diabetic rats and thus it may find clinical application to treat neuropathic pain in diabetic patients. lalitkishore000@gmail.com
Journal of Experimental Food Chemistry received 389 citations as per Google Scholar report
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