Therapeutic and toxic effects of Enantia chlorantha (Annonaceae) Stem Bark extracts in salmonella Typhi-induced rats

51^st World Congress on Microbiology & 13^th International Conference on Food Technology and Processing

May 24, 2022 WEBINAR

Merline Namekong Djimeli, Guy SedarSingor Njateng, Serge Secco Atsafack, Norbert Kodjio, Joseph M. Mendimi Nkodo and Donatien Gatsing

Laboratory of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O.Box 67 Dschang, Cameroon
Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Yaounde, Cameroon

Scientific Tracks Abstracts: J Food Ind Microbiol

Abstract :

Background: Bacteria are responsible for a large number of diseases worrying the world today. Medicinal plants have always been used by poor communities of the African continent as an alternative for the treatment of those diseases. Typhoid fever is one of those diseases caused by salmonella. The aim of this study was to investigate the in vivo antisalmonellal properties of medicinal plant called Enantia chlorantha. Methods: Salmonella typhi-infected rats daily received orally the various doses of 95% ethanolic extract of E.chlorantha stem bark (9.16, 36.5 and 73 mg/kg bw) or oxytetracyclin (20 mg/kg) for 9 days. Toxicity’s parameters as, hematology, transaminase (ALAT, ASAT), lipids profile, urea, creatinin, total proteins, body and organs weight were assessed. Results showed that the healing effect was marked by the absence of salmonella in animal’s blood cultured on ss agar. And this was observed after 6 days of treatment. Females and males rats recovered after 8 and 9 days of treatment respectively. The infection induced a significant reduction (p < 0.05) of the relative weight of male’s kidney and spleen and that of female’s heart; of urinary creatinin and urea, of the hepatic and kidney proteins. Significant increase (p < 0.05) of the white blood cells, granulocytes (in both sexes), blood platelet, transaminase and PAL activities, serum proteins, creatinin, total cholesterol, Triglycerides and LDL cholesterol was observed. The administration of extract corrected the dysfunction and lesions caused by the infection. The doses 36.5 and 73 mg/bw corrected damages with best protection. Conclusion: The overall results showed that Enantia chlorantha have therapeutic virtues against salmonella Typhi and then the potentials as future medicines and could act as potent prototypes for the development of plant-based natural antibiotics.

Biography :

Merline Namekong Djimeli is affiliated to the Laboratory of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O.Box 67 Dschang, Cameroon.