Background: Infrared (IR) and visible (VIS) radiations constitute approximately 95% of total solar radiation.
Although less energetic than UV radiation, IR and VIS radiations are also able to penetrate to the deeper layers of
the skin, promoting the generation of reactive oxygen species (ROS). Similar to UV-derived ROS, visible- and IRderived
ROS also cause cellular damage, promoting skin photoaging. This study aims to test whether an extract of
Polypodium leucotomos (Fernblock®) that decreases matrix metalloprotease-1 expression induced by UV light has a
comparable effect on MMP-1 expression induced by VIS- and IR radiation in a small group of volunteers.
Methods: Human volunteers took Fernblock® orally for 21 days, and then were irradiated with IR/visible light.
After 24 h, a biopsy was collected, and MMP1 expression was assessed by immunohistochemistry and real time,
Results: Oral intake of Fernblock® attenuated MMP1 expression induced by IR and visible light.
Conclusion: Oral intake of Fernblock® efficiently protected against the appearance of a key hallmark of
photoaging induced by IR/visible irradiation.