Yeganeh Davoudi, Minoo Mahmoodi*, Masoud Ghorbani, Mohammad Ali Nilforoushzade and Rahim Ahmadi
Atopic dermatitis (AD) is a major inflammatory skin disease. Most patients with atopic dermatitis have elevated serum levels of mast cells and IgE. Mesenchymal stem cell (MSC) has been applied for the therapy of allergic disorders due to its beneficial immunomodulatory abilities. We sought to investigate the safety and the efficacy of human adipose tissue-derived MSCs (hAT-MSCs) in mouse atopic dermatitis (AD) model and to determine the serum levels of mast cells (MC) and IgE after subcutaneous administration
Yeganeh Davoudi, Minoo Mahmoodi*, Masoud Ghorbani, Mohammad Ali Nilforoushzade and Rahim Ahmadi1
Atopic dermatitis (AD) is a type of inflammation of the skin. It results in itchy, swollen, red, and cracked skin. Mesenchymal Stem Cells (MSCs) could suppress allergic responses in AD. Indeed, the immunomodulatory ability of MSCs can be usefully applied for the treatment of autoimmune and inflammation – related diseases such as asthma, rhinitis and dermatitis. We aims to evaluate safety and efficacy in DNFB – induced atopic dermatitis mouse model after a subcutaneous infusion of xenogeneic human Adipose Tissue – derived MSCs (hAT-MSCs). Therefore, hAT-MSCs have possibility as a new drug for AD.
DOI: 10.37421/2684-4281.2021.8.307
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DOI: 10.37421/2684-4281.2022.9.348
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DOI: 10.37421/2684-4281.2022.9.357
DOI: 10.37421/2684-4281.2022.9.358
White spots on the skin are the result of melanocytes being destroyed by CD8+ T cells in the autoimmune condition known as vitiligo. Numerous studies indicate that oxidative stress is a significant contributor to the onset of vitiligo from the very beginning. Overproduction of reactive oxygen species (ROS) and ROS accumulation in vulnerable melanocytes are jointly caused by multiple factors. ROS, on the other hand, play a role in the production of autoantigens and melanocyte damage at the level of molecules, organelles and cells through a variety of pathways connected to melanocyte dysregulation. Autoantigen presentation is mediated by innate immunity, which acts as a bridge between adaptive immunity and oxidative stress, according to recent research. The final destruction of epidermal melanocytes is guaranteed by the recruitment of CD8+ T cells induced by cytokines and chemokines. In addition, the reinstatement and relapse of vitiligo can be explained by emerging concerns regarding resident memory T cells and regulatory T cells. In this article, we attempt to uncover additional connections between autoimmunity and oxidative stress, as well as new perspectives on recent developments in our knowledge of the disease's pathogenesis.
DOI: 10.37421/2684-4281.2022.9.359
The fight against aging, which is defined as a set of physiological mechanisms that alter the physical and intellectual capacities of humans, is one of the major challenges of the 21st century. This process includes more than just skin aging. Major healing defects are linked in part to changes in the biomechanical properties of skin cells, primarily dermal fibroblasts, that are associated with this condition. The immune system, which is also crucial for wound healing and maintaining skin homeostasis, is affected by time as well:Skin immunosenescence would result, promoting a pro-tumor environment while limiting the anti-infectious and vaccine responses. Before listing the effective anti-aging strategies to combat age-related dermal and epidermal stigmas, the primary skin damages caused by aging— whether intrinsic or extrinsic—will be discussed in detail.
DOI: 10.37421/2684-4281.2022.9.356
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DOI: 10.37421/2684-4281.2022.9.380
The Spanish Institute of Dermatology and Venereology (AEDV) has concluded that a Well defined course of action is anticipated to help the relationship with conforming to new conditions and anticipate unborn turns of events. To stick the AEDV as a clinical cooperation that can apply an impact in everything connected with dermatology. To add to the enhancement of the claim to fame, buttressing the eminence and notoriety of dermatology and dermatologists. To lay out a model for working and crucial logic that can be given on to progressive wastes of Chiefs and will empower the Foundation to distinguish unborn difficulties. The methodology used to foster the Well defined course of action was as per the following examination of patterns in the medical care frame; evaluation of the ongoing circumstance of AEDV and of dermatology overall through an inward disquisition in view of studies and meetings with scholastics; disquisition of rates, failings, implicit open doors, and troubles; readiness of a statement of purpose; and recognizable evidence, enhancement, and prosecution of a fashion chart fastening on essential lines of exertion. The procedure chart put forth out 16 general objects assembled into 4 abecedarian points (negotiating the vision, inward and outdoors guests, inside cycles, and advancement) and nitty gritty in an exertion plan with 19 drives, each with unequivocal conditioning. The arrangement will be checked by the well defined course of action Observing Council, which is comprised of the individualities from the Standing Board of trustees and the seats of the 9 Specialized Advisory groups answerable for executing the drives.
DOI: 10.37421/2684-4281.2022.9.384
DOI: 10.37421/2684-4281.2022.9.381
Azathioprine is employed as an immunosuppressant and corticosteroid- saving specialist for the treatment of a many cutaneous ails. The change of thiopurine methyltransferase (TPMT) and inosine triphosphat pyrophosphatase (ITPA) has been reckoned for to bring about the collection of dangerous thiopurine metabolites and to expand the negative impacts during azathioprine treatment. In the Chinese crowd, TPMT ∗ 3C and ITPA C94A polymorphisms have been archived. Genotyping was performed for TPMT and ITPA polymorphisms in 92 inapplicable solid workers and in 74 dermatology cases polymorphisms, TPMT ∗ 3C and ITPA C94A, were linked. After disquisition, ITPA C94A showed helpless relationship with queasiness/ regurgitating incited by azathioprine. either, we uncovered that the ITPA 94 An allele was most normal in cases with queasiness/ retching and growing sluggish evident unfriendly impacts (67), traced by cases with sickness/ spewing yet not growing sluggish acting unfavourable impacts (half) and cases without sickness/ heaving still growing sluggish evident unfriendly impacts (25).
DOI: 10.37421/2684-4281.2023.10.385
Aging skin is a natural consequence of the aging process and is influenced by both intrinsic and extrinsic factors. Intrinsic factors, such as genetics and hormonal changes, contribute to the gradual decline in collagen and elastin production, resulting in thinning, dryness and the appearance of fine lines and wrinkles. Extrinsic factors, such as sun exposure, smoking and environmental pollutants, further accelerate the aging process by causing damage to the skin's cellular structure. This damage manifests as age spots, uneven pigmentation and a loss of firmness and elasticity. Understanding the causes and effects of aging skin is essential for implementing effective care strategies. Sun protection, gentle cleansing and moisturizing are crucial in maintaining skin health. Additionally, the use of anti-aging ingredients, such as retinoids, peptides and antioxidants, can help minimize the visible signs of aging. By adopting a comprehensive approach to skincare, individuals can promote the health and vitality of their aging skin, resulting in a more youthful and radiant appearance.
DOI: 10.37421/2684-4281.2023.10.386
Dermato-oncology is a rapidly evolving field that focuses on the diagnosis and treatment of skin cancer. Skin cancer is one of the most prevalent malignancies worldwide and its incidence continues to rise. Over the past few decades, significant advancements have been made in the understanding, detection and management of skin cancer, leading to improved outcomes for patients. This abstract highlights some of the key advancements in skin cancer diagnosis and treatment within the field of dermato-oncology. It begins by discussing the utilization of advanced imaging techniques, such as dermoscopy, confocal microscopy and optical coherence tomography, which have revolutionized the early detection and accurate diagnosis of skin cancer. These non-invasive imaging modalities enable clinicians to visualize the skin at a cellular and subcellular level, aiding in the identification of suspicious lesions and facilitating timely intervention. Additionally, the abstract explores the growing importance of molecular diagnostics in skin cancer management. Molecular profiling techniques, including next-generation sequencing and gene expression profiling, have unveiled crucial insights into the genetic alterations and signalling pathways involved in different types of skin cancer. This molecular information allows for personalized treatment approaches and targeted therapies tailored to the specific genetic makeup of individual tumours, resulting in improved treatment outcomes.
DOI: 10.37421/2684-4281.2023.10.387
DOI: 10.37421/2684-4281.2023.10.388
Dark circles are a common cosmetic issue that can affect individuals of all ages and genders. While they are typically harmless, dark circles can make a person appear tired, aged and less vibrant. This article provides a comprehensive overview of the causes, myths and treatments associated with dark circles. The causes of dark circles range from genetic factors to lifestyle choices, such as lack of sleep and sun exposure. Debunking common myths, it clarifies that inadequate sleep is not the sole cause and that topical creams may not completely eliminate dark circles. The article offers various treatment and prevention strategies, including skincare routines, lifestyle changes, home remedies, medical treatments and camouflage techniques. However, it emphasizes that individual results may vary and professional advice should be sought if dark circles persist. By understanding the causes and implementing appropriate strategies, individuals can minimize the appearance of dark circles and achieve a brighter, rejuvenated under-eye area.
DOI: 10.37421/2684-4281.2023.10.389
Journal of Dermatology and Dermatologic Diseases received 4 citations as per Google Scholar report
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