Journal of Dermatology and Dermatologic Diseases

ISSN: 2684-4281

Open Access

Khaled Ezzedine

Department of Dermatology, EpiDermE - Epidemiology in Dermatology and Evaluation of Therapeutics, F-94010 Creteil, France

  • Mini Review   
    Immunology of Vitiligo
    Author(s): Khaled Ezzedine*

    White spots on the skin are the result of melanocytes being destroyed by CD8+ T cells in the autoimmune condition known as vitiligo. Numerous studies indicate that oxidative stress is a significant contributor to the onset of vitiligo from the very beginning. Overproduction of reactive oxygen species (ROS) and ROS accumulation in vulnerable melanocytes are jointly caused by multiple factors. ROS, on the other hand, play a role in the production of autoantigens and melanocyte damage at the level of molecules, organelles and cells through a variety of pathways connected to melanocyte dysregulation. Autoantigen presentation is mediated by innate immunity, which acts as a bridge between adaptive immunity and oxidative stress, according to recent research. The final destruction of epidermal melanocytes is guaranteed by the recruitment of CD8+ T cells induced by cyto.. Read More»
    DOI: 10.37421/2684-4281.2022.9.358

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Citations: 4

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