Kidney transplant or renal transplant is the organ transplant of a kidney into a patient with end-stage kidney disease (ESRD). Kidney transplant is typically classified as deceased-donor (formerly known as cadaveric) or living-donor transplantation depending on the source of the donor organ.
Henkie P Tan
The tolerance of organ transfers is very much archived. Upgrades in immunosuppression and different parts of subordinate consideration have prompted critical improvement in results. Right now, regardless of extensive examination struggle, there are a couple of demonstrated tests pointed toward estimating or observing the ampleness of immunosuppression, the disappointment of which may result in over-immunosuppression and pioneering diseases and kidney brokenness, or under-immunosuppression and intense dismissal (AR).
DOI: 10.37421/2161-0991.2021.11.180
DOI: 10.37421/2161-0991.2021.11.182
Michelle Burgin, Roxana Beladi, Kyle Varkoly, Jordan R. Yaron, Liqiang Zhang, Steve T. Yeh, Jacqueline Kilbourne, Dara Wakefield, William Clapp, Alexandra R. Lucas
Weems Juston, Holman John1, Rose Stanley, Abecassis Michael M , Levitsky Josh
Background: We have previously discovered and validated a microarray-based test that analyzes blood gene expression profiles (GEP) as an indicator of immune status in liver transplant recipients with stable liver function.
Methods: In this study, investigators (7 transplant hepatologists) assessed clinical utility of the TruGraf Liver test in patient management. In a retrospective study, simultaneous blood tests and liver function tests (882 serial time points within the first year of liver transplant) were performed in 29 patients at 7 transplant centers.
Results: When queried regarding whether a single initial TruGraf Liver test result impacted their decision regarding patient management, in 455/882 (51.5%) of serial time points, the investigator responded in the affirmative. Of the 455 affirmative responses, nearly 70% were related to the test result supporting a decrease or increase in immunosuppressive therapy. Of the responses that TruGraf liver did not alter care, nearly 40% were related to the need to see the next serial test before modifying patient management. All seven providers (100%) stated the affirmative when asked if this blood test would be useful in general for future liver transplant patient management.
