Chronic Granulomatous Disease (CGD) is a rare, inherited immunodeficiency disorder characterized by dysfunctional phagocytes, rendering affected individuals highly susceptible to recurrent and severe infections. Hematopoietic Stem Cell Transplantation (HSCT) has emerged as a promising curative therapy for CGD, offering the potential for restored immune function. This review explores the clinical application of HSCT in CGD, analyzing the historical and contemporary aspects of the procedure, associated challenges and patient outcomes. Keywords include risk assessment, donor selection, Graft-Versus-Host Disease (GVHD), conditioning regimens and long-term follow-up. The findings underscore the significance of HSCT as a potentially curative approach for CGD, while emphasizing the importance of continued research and multidisciplinary collaboration for optimal patient care.
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Transplantation Technologies & Research received 223 citations as per Google Scholar report
