Transplantation Technologies & Research

ISSN: 2161-0991

Open Access

Article in Press

Volume 10, Issue 3 (2020)

    Research Article Pages: 1 - 4

    Human T-Cell Lymphoma Virus-Positive Allograft Used For Effective Orthotopic Liver Transplantation: A Case Report and Review of the Literature

    TR Harring, NT Nguyen, JA Goss and CA O’Mahony

    Introduction: The human T cell lymphoma virus was screened for previously in organ donors secondary to concern for progressive disease in an immunocompromised host. However, due to the low prevalence of the virus, a shortage of suitable allografts, and the lack of a time effective test, this practice has been abandoned in the United States. The human T cell lymphoma virus type I may cause progression to several diseases, including human T cell lymphoma virus associated myelopathy, and adult T cell lymphoma/l eukemia. Moreover, there is an overall lack of data relating to the safety profile in the medical literature with use of human T cell lymphoma virus positive allografts.

    Aim: To determine the safety of human T cell lymphoma virus positive allografts in orthotopic liver transplantation.

    Materials and Methods: Our database was queried for recipients of known human T cell lymphoma virus positive allografts at time of transplantation. We present one patient case report followed by a review of the medical literature.

    Results: The patient was transplanted secondary to cirrhosis due to alcohol and hepatitis C virus infection with hepatocellular carcinoma. When a suitable allograft became available, the patient was advised that it was human T cell lymphoma virus type I positive. The risks and benefits were discussed thoroughly with the patient and he elected to proceed with the operation. His operation and post operative course were unremarkable. He continues to do well during on follow up of over 777 day s, and currently he has no symptoms of any human T cell lymphoma virus associated disease. Review of the medical literature demonstrates few reports on human T cell lymphoma virus related complications after orthotopic liver transplantation; however, the re are theories that immunosuppresion may cause progressive disease in these patients.

    Conclusions: Human T cell lymphoma virus type I positive donors can be life saving sources of allografts. Our center supports the use of these allografts in patients that otherwise continue to be on the waiting list.

    Volume 11, Issue 4 (2021)

      Editorial Pages: 1 - 1

      Bone Marrow is Implanted the Amount of Oxidative

      Clelia Rejane Antonio Bertoncini

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      The tail-cuff method was used to assess systolic blood pressure, as previously described. At 48 weeks of age, the rats were assessed, with 2 days of tail-cuff blood pressure training followed by 3 days of measurements. On each measurement day, two sets of measurements were taken, each with up to five independent measurements. Animals were tested on a daily basis at roughly the same time.

      Stroke is the leading cause of motor impairments and a leading cause of death around the world. Adult stem cells have been found to protect neurons from degeneration through mechanisms that include neurotransmitter activity recovery as well as a reduction in apoptosis and oxidative stress. As a model for stem cells, we used the lineage stroke-prone spontaneously hypertensive rat (SHRSP).Recent research suggests that to restore the loss of cells in the nervous system, particular combinations of therapies are required, based on the already existing neural network as well as the blood supply and intrinsic mechanisms of healing. MSCs have been shown to give birth to neural cells in vitro and in vivo in numerous investigations. Bone marrow stem cells may become involved after an ischemic event

      Editorial Pages: 1 - 2

      Children abnormalities on brain MRI

      Sally Emad-Eldin

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      For a variety of childhood hematologic malignancies as well as to treat congenital disorders in which these functions are diminished or missing, bone marrow transplantation (BMT) is used to restore hematologic and immunologic competence. High doses of chemotherapy, often combined with total-body irradiation, are used to prepare the patient for BMT. Infection, vascular problems, therapy-induced cytotoxicity, graft versus host disease (GVHD), and return of preexisting diseases are the most prevalent and clinically important consequences. Because CNS consequences can be catastrophic, early diagnosis is critical for successful management and a good prognosis. CT and MRI scans are useful for early diagnosis, which increases the chances of a successful treatment.

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