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Immunogenic Reaction | Open Access Journals
Journal of Immunobiology

Journal of Immunobiology

ISSN: 2476-1966

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Immunogenic Reaction

Immunogenicity is the ability of a foreign substance, such as an antigen, to provoke an immune response in the body of a human or another animal. In other words, immunogenicity is the ability to induce a humoral and/or cell-mediated immune responses. The distinction is made between wanted and unwanted immunogenicity: Wanted immunogenicity is typically related to vaccines, where the injection of an antigen (the vaccine) provokes an immune response against the pathogen (virus, bacteria), protecting the organism from future exposure. Vaccine development is a complex multi-step process, with immunogenicity being at the center of vaccine efficacy. Unwanted immunogenicity is an immune response by an organism against a therapeutic antigen (ex. recombinant protein, or monoclonal antibody). This reaction leads to the production of anti-drug antibodies (ADAs) inactivating the therapeutic effects of the treatment and, in rare cases, inducing adverse effects. A challenge in biotherapy is predicting the immunogenic potential of novel protein therapeutics. For example, immunogenicity data from high-income countries are not always transferable to low-income and middle-income countries. Another challenge is considering how the immunogenicity of vaccines changes with age. Therefore, as stated by the World Health Organization, immunogenicity should be investigated in a target population since animal testing and in-vitro models cannot precisely predict immune response in humans.

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Citations: 34

Journal of Immunobiology received 34 citations as per Google Scholar report

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