Journal of Immunobiology

ISSN: 2476-1966

Open Access

Current Issue

Volume 6, Issue 2 (2021)

    Editorial Pages: 1 - 2

    Cancer: All about a Minute Cell Which Multiplies in Numbers Making Loose Hope on Life

    Nicholas van Panhuys

    Cancer is a deadly disease which can be understood as the death of the cell, with no specific reasons known till today, the diagnosis of cancer can be done in certain stages where in initial stages it is unable to diagnose in some conditions. In other words cancer is also called as Malignancy. In today’s era there is a multiple mortality rate due to different types of cancer. Due to the unknown reason for the cause it affects all ages starting with neonates to the adultery .In some cases the cancer is cured and in some cases the treatment of the cancer may not bring out any results. Well coming to the cancer with additional diseases causing the disease to be more powerful than the will power of the human. There is no reason why it is affecting a specific person irrespective of age and gender. There are types of cancers like leukemia, brain tumor, osteomyelitis gastrointestinal cancer, Breast cancer etc. depending on the affected area the treatment varies some needed the radiotherapy and some require the removal of the tumor cell in order to affect their capacity to multiply. There are many advanced techniques in treatment of cancer like the surgeries and chemotherapy with additional medication. The chance of the life survival of a person after treatment depends on many conditions like the age and the personal health conditions some cancers can be treated with chemotherapy where the chance of survival can be predicted when coming to surgeries the chances are unpredicted. In adultery the treatment of cancer is a bit unpredicted where the already body aligning health conditions do not help the fast recovery or the recovery of cancer.

    Review Article Pages: 1 - 4

    Individualized Multimodal Immunotherapy for DIPG: Part of the Game?

    Stefaan W. van Gool*, Jennifer Makalowski, Tobias Sprenger, Volker Schirrmacher and Wilfried Stuecker

    In 2020 a study, entitled, Addition of multimodal immunotherapy to combination treatment strategies for children with Diffuse Intrinsic Pontine Glioma: A single institution experience was published in Medicines. The text reports the final analysis of 41 children treated with Individualized Multimodal Immunotherapy (IMI) as part of their (combined) treatment schedule. All these children came upon individual request or were referred by the physician to the Immune Oncologic Centre in Köln ( Since May 2015, the IOZK has the official approval to produce under GMP conditions (DE_NW_04_GMP_2015_0030 and DE_NW_04_GMP_2020_0054) autologous Dendritic Cells (DCs) loaded with autologous tumor antigens and matured in the presence of IL-1b, IL-6 and TNF-a together with GMP-produced Newcastle Disease Virus (NDV). This Advanced Therapy Medicinal Product (ATMP), registered as IO-Vac®, is approved as medicinal product and as experimental medicinal product for use in human (DE_NW-04-MIA-2015-0033 and DE-NW-04-MIA-2020-0017). IO-Vac® is the drug used for active specific immunotherapy. IOZK is a private non-profit organization and delivers, besides 1) IO-Vac® DC vaccines, also 2) Immunogenic Cell Death (ICD) therapies with the Oncolytic Virus (OV) Newcastle Disease Virus (NDV) and modulated electro hyperthermia ,eventually inserted in chemotherapy regimens; 3) passive immunotherapy with antibodies, 4) modulatory immunotherapy with antibodies and/or low dose metronomic chemotherapy regimens and/or total body hyperthermia (brain lesions belong to exclusion criteria for this technology) and 5) finally a whole set of complementary medicinal strategies to improve immune reactivity.

    2021 Conference Announcement Pages: 1 - 1

    36th International Conference on Immunology, April 26-27, 2021

    Elizebth Marnon

    Conference Series invites all the participants across the world to attend 36th International Conference on Immunology to be held during April 26-27, 2021 which includes prompt keynote presentations, Oral talks, e-Poster presentations, Young Research Forum (YRF) and Exhibitions.

    Market Analysis Pages: 1 - 1

    International Conference on Immunology & Immunotherapies April 27, 2021

    Le Minh Sat

    Warm Welcome to all as we affably invite you to be a part of the International Conference on Immunology & Immunotherapies April 27, 2021 (Webinar). We invite all the participants from all across the globe to attend “Immunology & Immunotherapy” conference during April 27-2021 Webinar which includes prompt keynote presentations, poster and oral talks. This conference plays a Global platform for biomedical companies, clinical research divisions, professionals, specialists, consultants, doctors, scholars and students to frame a new relationship and build up the Knowledge. This is a wonderful opportunity for all the delegates to interact with the top grade world class Scientists. The particular members can confirm their participation through Registrations.

    2021 Conference Announcement Pages: 1 - 1

    Tumor & Cancer Immunology and Pediatric-Oncology April 15-16, 2021

    Elizebth Marnon

    With members from around the world focused on learning about Tumor and Cancer immunology and its advances: this is your best opportunity to reach the largest assemblage of participants from Tumor & Cancer immunology community. conduct presentations, distribute information’s, meet with current and potential scientists, make a splash with new drug developments, and receive name recognition at this 2-day event, world-renowned speakers, the most recent techniques, developments, and the newest updates in Tumor & Cancer immunology are hallmarks of this conference.

    Volume 6, Issue 4 (2021)

      Research Article Pages: 1 - 7

      Susceptible Role of Saccharin Mixture in Induction of Inflammation Through Action on Interleukin-10 and its Receptor

      Azza El Amir*, Wajeet Nabil, Marwa M. Eldaly and Mohamed Hosney

      DOI: 10.37421/2476-1966.2021.6.163

      Sodium cyclamate and saccharin mixture is a common artificial sweetener used as a food additive and it was found to be accompanied with increase relevance of inflammation including IBD. The causes of IBD are unknown, but many immune, genetic and environmental factors play a role as causative agents of that disease. The consumption of artificial sweeteners was related to the appearance of inflammation including IBD. The present study was aimed to evaluate the effect of sodium cyclamate and saccharin mixture as artificial sweeteners on immune system in albino mice through assessment of IL-10 cytokine and its receptor. Fifty male albino mice grouped into control group (n=20) receive only tap water and treated groups (n=30) received 60 mg/kg body weight sodium cyclamate and saccharin mixture in tab water for 12 weeks. Mice were sacrificed twice at the 6th and the 12th weeks. Collected blood measured low concentration of IL-10 cytokine by the sandwich ELISA. While, expression levels of IL-10R1 and IL-10R2 were assessed in colorectal tissue samples using Real time PCR. The results demonstrate significantly overexpression of IL-10R1 and IL-10R2 at 6th week than 12th week treated mice was recorded. Also, more congestion of RBCs, focal aggregation, focal necrosis, and focal infiltrations between glands in the lamina propria at 12th week treated group than 6th week treated group were observed. In conclusion, sodium cyclamate and saccharin mixture induced inflammation that may be risk for IBD by alteration in gene expressions of IL-10R1 and IL-10R2 in male albino mice.

      Commentary Pages: 1 - 2

      The Broad Biological Significance of Eicosanoids in Invertebrates

      David Stanley and Yonggyun Kim*

      We present a brief sketch of the discovery of prostaglandins and other eicosanoids in human and veterinary biomedicine, and then comment on their significance in invertebrates, all reviewed in detail elsewhere. Here we bring out a few points. One, PG biosynthesis in insects follows a mechanism different from mammals. Two, insect systems are amenable to functional studies of specific genes operating in eicosanoid systems via RNAi and CRISPR-Cas9, which has accelerated understanding of genes involved in PG synthesis and in receptor-mediated actions. We suggest research into some model insect systems, particularly Drosophila melanogaster and the moth Spodoptera exigua, may lead to broadly useful insights into PG actions.

      Case Report Pages: 1 - 3

      Novel and Effective Treatment for Patients with COVID-19 in Stages I to IIIA of the Infection

      Ronald Palacios Castrillo*

      DOI: 10.37421/2476-1966.2021.6.160

      We report here a novel treatment for patients with Covid-19, stages I to IIIA of infection. The combination of Nitazoxanide, Hydroxicloroquine and Zinc effectively eliminated the SARSCov2 virus after 10 days of treatment in 165 of the 172 patients studied, as determined by RT-PCR and antigen in nasal swabs. This triplet of medicines along with Deflazacort and Ribaroxaban successfully treated patients in stages IIB to IIIA of the infection .The treatment described here is readily available, inexpensive and should prove useful to control dissemination and spread of the virus by symptomatic and asymptomatic persons as well as to decrease the mortality.

      Review Article Pages: 1 - 5

      JAK/STAT Pathway in Gastric Cancer and its Potential Therapeutic Implications

      Iqra Jan*

      DOI: 10.37421/2476-1966.2021.6.164

      Normal functioning of Gastric epithelial cells needs continuous check over multiple signaling pathways. Dysrhythmic behavior of any of the pathways at any of the steps can lead to unleashing of devastating effects. Tracking these abnormal steps can be a way forward for controlling the aggressiveness of these cells. Here in this review we have summed up various studies in order to link different hierarchies of the key pathway leading to gastric cancer. Out of all, JAK/STAT pathway is considered to be a master regulator for cell signaling. Abnormal functioning of JAK/STAT pathway at any of the steps ranging from inflammation caused by Helicobacter pylori to its negative regulator SOCS-1 can bring about the devastating nature of this pathway which ultimately leads Gastric Carcinoma. However in this review we have tried to track different steps of this pathway to find out the possible means of impeding the aggressiveness caused due to any abnormality.

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Citations: 112

Journal of Immunobiology received 112 citations as per Google Scholar report

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