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Journal of Antimicrobial Agents

ISSN: 2472-1212

Open Access

Current Issue

Volume 7, Issue 3 (2021)

    Review Article Pages: 1 - 6

    Antiseptic Action of E-101 Solution, a Myeloperoxidase-Mediated Formulation, in the Presence of Whole Blood Compared to Conventional Wound Antiseptics and Biocides

    Gerald A. Denys*, Jessica L. Carpenter, Robert C. Allen and Jackson T. Stephens Jr

    E-101 solution is a first-in-class myeloperoxidase containing antimicrobial solution developed for topical application. The active ingredients in E-101 solution are two enzymes, porcine myeloperoxidase (pMPO) and glucose oxidase (GO) in an aqueous solution and activated by the addition of a glucose solution. Once activated, the reactive species hydrogen peroxide, hypochlorous acid/hypochlorite (HOCl/OCl-), and singlet oxygen (1O2) are generated. We evaluated the effect of whole human blood on the performance of E-101 solution compared to commercially available wound antiseptics and commonly used biocides. The wound cleansers NeutroPhase, Microcyn, and Vashe with the active HOCl/OCl- component were tested according to the USP-51 effectiveness test in the presence of 0, 1, 2 and 5% blood. Comparative time-kill studies against chlorhexidine, povidone-iodine, sodium oxychlorosene were tested in the presence of 0, 2, 5 10, and 20% blood. In the USP-51 test, E-101 solution demonstrated >2 log10 reduction against bacterial and fungal isolates in the presence of 5% blood at days 14 and 28. With the exception of NeutroPhase activity against S. aureus, all comparable wound antiseptics demonstrated <2 log10 reduction in the presence of 5% blood at days 14 and 28. Time-kill microbicidal data observed in the presence of blood demonstrated that E-101 solution was the most active biocide, followed by chlorhexidine and povidone-iodine. The presence of 2% blood completely inhibited the activity of sodium oxychlorosene. In summary, E-101 solution remained active in the presence of blood containing catalase and other substances that competitively react with 1O2 and HOCl/OCl- as a safe and effective wound antiseptic
    Awards 2020 Pages: 0 - 1

    3rd World Summit on Virology, Vaccines & Emerging Diseases

    Giulio Tarro

    The Award tries to perceive works of qualification and is given for recognized and extraordinary accomplishments in all fields of disciplines. Awards are don't just recognize achievement; they perceive numerous different characteristics: capacity , battle, exertion and, most importantly , greatness and hard work.
    Awards 2020 Pages: 1 - 2

    3rd Global congress on Antibiotics and AMR

    Farid menaa

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    Young Research Forum Pages: 0 - 1

    4th World Congress on Rare Diseases and Orphan Drugs

    Giulio Tarro

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    Volume 7, Issue 4 (2021)

      Research Article Pages: 1 - 4

      Antibacterial and Antifungal Properties of Essential Oil Blends

      Jillian A Parker*, Eduardo Encina and Antony DG Jones

      Pathogenic microorganisms represent an ever-increasing human health concern. Simultaneously, there is an increased desire for naturally derived, antimicrobial agents for use in consumer products. Essential oils, which are derived from natural plant materials and typically have a long history of use, are sources of alternative, non-antibiotic antimicrobial agents. In particular, oregano (Origanum vulgare) oil and its respective constituents have been shown to have antimicrobial properties. In this study, the minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) of two essential oil formulations containing oregano oil as the main constituent were determined. Results showed that the essential oil formulations effectively inhibited growth of Escherichia coli with MBCs of around 2.0-5.7 mg/mL in vitro. Additionally, the formulations exhibited MFCs of 2.8-4.0 mg/mL and 1.4-2.0 mg/mL against the fungal species Candida albicans and Candida auris, respectively. The demonstrated antibacterial and antifungal properties of these naturally derived antimicrobial formulations provide a ‘greener’ alternative than traditional synthetic chemicals that may be useful in consumer products, such as cleaning agents

      Brief Report Pages: 1 - 4

      A Brief Report of Environmental Contamination with Gram-Negative Bacteria at Front-Line Hospitals in Northern Syria

      Fariba Nayeri

      Daily operations on wounded soldiers are performed at front-line hospitals. Because diagnostic procedures are not easily available during war and antibiotics are given to patients with suspected infection, it is crucial to assess the resistance patterns of pathogens that colonize the environment at hospitals in order to establish routines and guidelines to decrease antibiotic misuse. In this study, we assessed the source of postsurgical infection caused by multiple resistant gram-negative bacteria by performing culture tests in water samples taken from wastewater, a sink in the operation room, and soap at intensive care units from five military hospitals in northern Syria. Although it was not possible to further characterize the bacteria found on the agarose dishes, cultures taken from moist environments at intensive care units grew colonies of gram-negative bacteria resistant to several available antimicrobial agents. In conclusion, we found that colonized bacteria in pipes, wastewater, soap, or bottles containing disinfectants may be sources of nosocomial infection in postoperative patients. Environmental assessment and regular controls are needed to yield valuable information regarding contamination and the susceptibility of bacteria to antimicrobial agents.
      Research Article Pages: 1 - 4

      Spike Sars-COV-2 Protein as Procoagulant Factor and Vaccine Class Effect Hypotesys

      Luisetto M*, Naseer Almukthar, Tarro G, Farhan Ahmad Khan, Khaled Edbey, Gamal Abdul Hamid, Mashori G R, Ahnaf Ilman, Nili B.A, Fiazza C,Yesvi R, Jameel Ahmad and Latyshev O. Y

      This work is written in actual situation by which some covid vaccine are under deeply investigation related some rare cases of thrombosis. It is really interesting to observe the literature that have reported in first and second Ô?? third wave of covid-19 disease a relationship with increase thrombosis in the most severe patients. So it is possible to say that there is a procoagulant property of covid-19 virus. But this property is related to all virus particle or it can be mediated or due by the spike-protein? And if there is this relationship it was a real good feature di project vaccine based on this protein? To investigate in this direction can be a good instrument to better understand some unclear aspect of this Vaccine rapid production
      Awards 2020 Pages: 1 - 1

      Antibiotics 2020

      Dinesh Jaiswal

      The awards are presented to the individuals to recognize their continued hard work in bringing the future of drugs to treat many diseases. The objective of Antibiotics 2020 Awards is to honor brilliance and acknowledge the innovation, hard work and accomplishment of Antibiotics researches and products with an Award, Memento and Certificates.
      Awards 2020 Pages: 1 - 1

      Medical Biotechnology 2020

      Magnus S Magnusson

      In recent years, the field of medical biotechnology has experienced rapid growth, leading to the development of several innovative techniques for disease prevention, diagnosis and treatment. New methodologies, including polymerase chain reaction, gene sequencing.

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