DOI: 10.37421/ 2472-1212.2022.8.255
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DOI: 10.37421/2472-1212.2022.8.284
Salmonella, Campylobacter, Listeria, Staphylococcus spp. and Escherichia coli infections with multidrug resistance are a problem in the poultry industry. Antibiotics alter the normal microbiota's delicate balance, resulting in symbiosis, immunosuppression and the emergence of secondary infections. Salmonella and Campylobacter colonisation in poultry has reportedly been reduced by bacteria phages. Bacteriophages can be combined with antibiotics to increase antibacterial activity because their specificity is higher than that of antibiotics. In order to specifically eradicate bacterial pathogens, species-specific phage’s have been developed, such as Staphylophage .For efficient biosecurity and biosafety measures, bacteriophage products such as BacWashTM and Ecocide PX have been developed as antiseptics and disinfectants. Phage therapy's effectiveness is influenced by the duration of use, the quantity.
DOI: 10.37421/2472-1212.2022.8.286
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DOI: 10.37421/2472-1212.2022.8.285
One of the most frequently used essential oils in the field of aromatherapy is Cinnamomum velum L. essential oil also known as Ceylon cinnamon or cinnamon tree. It serves as an astringent, antipruritic, rubefacient and antiseptic agent when applied externally. Additionally, both in vitro and in vivo studies have shown its wide range of pharmacological effects, including the potential to treat headache, migraine, myalgia and neuralgia. Numerous studies have also supported its potent antiviral and antimicrobial qualities. The most representative substances that are typically present in greater quantities in and are crucial in determining its pharmacological activities are cinnamon aldehyde, eugenol, caryophyllene, cinnamyl acetate and cinnamic acid. Because of the situation with antibiotic resistance globally and the decreasing funding for developing.
DOI: 10.37421/2472-1212.2023.9.294
Echinocandins disrupt cell wall synthesis, weakening the fungal cell. Allylamines block ergo sterol production, hindering fungal growth. Combination therapy and emerging agents are also briefly mentioned. Consideration of potential side effects and drug interactions is essential. This abstract emphasizes the importance of anti-fungal agents in combating fungal infections and the ongoing research in this field to address the emergence of drug-resistant strains. These diseases are caused by fungi that can flourish in a variety of conditions and spread rapidly to people with weakened immune systems. Treatment plans have also become more challenging as a result of the rising incidence of drugresistant fungus strains and the increased usage of immunosuppressive medications.
DOI: 10.37421/2472-1212.2023.9.295
Antimicrobial drugs, including fluoroquiAntibiotics: Antibiotics are used to treat bacterial infections. They can be further classified into several categories, such as penicillin, cephalosporin, macrolides, tetracycline and fluoroquinolones. Each category has a unique mode of action and targets specific bacteria or bacterial components Inhibition of cell wall synthesis: Many antibiotics, such as penicillin and cephalosporin, interfere with the synthesis of bacterial cell walls. By disrupting this essential structure, the drugs weaken the bacteria, making them more susceptible to destruction by the immune system. Inhibition of protein synthesis: Certain antibiotics, like macrolides and tetracycline, inhibit bacterial protein synthesis. By blocking the production of vital bacterial proteins, these drugs impede bacterial growth and reproduction. Inhibition of nucleic acid synthesis: Antimicrobial drugs, including fluoroquinolones, interfere with the synthesis of bacterial DNA or RNA. This disruption prevents bacteria from multiplying and spreading, aiding in the eradication of the infection.
DOI: 10.37421/2472-1212.2023.9.296
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DOI: 10.37421/2472-1212.2025.11.378
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Tory M. Johnson and Zhengxin Wang*
DOI: 10.37421/2472-1212.2025.11.378
T. arborvitae has been employed for its medicinal efficacy, especially for the treatment of bacterial infections. In this study, the aim was to isolate and analyze the antibacterial activity of bioactive materials from Thuja leaf extract. Both Gram-positive Staphylococcus aureus and Streptococcus mutans, as well as Gram-negative Acinetobacter baumannii, Escherichia coli, and Pseudomonas aeruginosa, were inhibited by the methanol extract. During the purification process, three distinct bioactive compounds P1, P2, P3 and P4 were separated. The purified compounds exhibited antibacterial activity with MICs between 10-50 µg/ml. All P1, P2, and P3 were remarkable against the multi-drug resistant strain Acinetobacter baumannii. These results support the effectiveness of the compounds from T. arborvitae proving their value in developing new therapeutic agents.
Journal of Antimicrobial Agents received 444 citations as per Google Scholar report
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