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Journal of Antimicrobial Agents

ISSN: 2472-1212

Open Access

Articles in press and Articles in process

    Market Analysis Pages: 1 - 1

    Market Analysis Report of Micro Biology 2020

    David Hamer

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      Research Article Pages: 1 - 4

      Reem Rabie Mohammed Salih* and Haytham Hashim Gibreel

      The aim of this study is to evaluate antimicrobial effect leaves aqueous extracts against human and animal infectious bacterial strains. The leaves were air-dried, powdered and water extracted at concentration of 0.2 g/ml, 0.4 g/ml and 0.5 g/ml and were tested aginst different bacterial pathogens (Staphylococcus aureus, Staphylococcus epidermidis, Escherichia coli, Klebsiella pneumonia and Salmonella dublin); the antibacterial assay carried using agar diffusion method. Data of antimicrobial effect (inhibition zone in “cm”) was subjected to analysis of variance using SAS software where Duncan Multiple Range Test was used for means separation at P=0.05. The results indicated that, leaves of the species showed antimicrobial potential at tested concentrations (0.2, 0.4 and 0.5 g/ml). The results of analysis of variance indicated that, the diameter (cm) of inhibitory zone within the studied bacterial strains increases significantly as concentration increased. The lowest average inhibitory zone (cm) was 1.4 ± 0.07 recorded in Salmonella dublin at low concentration (0.2 g/ml), while 1.9 ± 0.05 (cm), 1.9 ± 0.06 (cm) and 1.9 ± 0.07 (cm) were the highest average inhibitory zone obtained by application of 0.5 g/ml leaves aqueous extract against Escherichia coli, Staph aureus and Staph epidermidis respectively.
      Research Article Pages: 1 - 6

      M. M El-ajaily*, M. M. Miloud, T. H. Al-noor, R. K. Mohapatra and N. S. Al-barki

      A Schiff base (HL1), namely; [(S, Z)-2-((2-hydroxy-1-phenylethylidene) amino)-3-(4-hydroxyphenyl) propanoic acid] was synthesized by the condensation of 2-hydroxyacetophenone with an amino acid (L-Tyrosine) for one hour. Whereas, the other Schiff base (HL2), namely; (E)-4-((2-(2, 4-dinitrophenyl) hydrazono) methyl)-N, N-dimethylaniline] was synthesized by refluxing 4- dimethylaminobenzaldehyde and 2, 4-dinitrophenylhydrazine for one hour. The first Schiff base (HL1) used ad primary ligand and the second one is used as secondary ligand to form five mixed ligand complexes with Co(II), Ni(II), Cu(II), Zn(II) and Fe(III) ions. The synthesized mixed ligand complexes were subjected to several physiochemical techniques, in terms; CHN elemental analyses, molar conductivity, magnetic moments and spectroscopic tools (FT-IR, 1HNMR, electronic, E.P.R and mass spectra). The analytical and spectroscopic data showed the presence of an octahedral geometry for all the mixed ligand complexes. The free Schiff bases, metal salts and mixed ligand complexes were tested for their antifungal activities on some pathogenic fungi species [A. niger, A. flavus, Alternaria alternata, Rhizopus stolonifer].

        Mini Review Pages: 1 - 2

        Andrew A Yabusaki*

        The selection of inpatient empiric antibiotic regimens is a significant challenge for hospitalists and clinicians today. Much is known about the increased incidence of acute kidney injury associated with the use of vancomycin and piperacillin-tazobactam in combination compared to vancomycin and other beta-lactam combinations. What is less clear is the incidence of antibiotic associated acute kidney injury and outcomes in Black patients. Incidence rates of acute kidney injury are already known to be higher in Black patients compared to white patients, which makes extrapolating the risks of antibiotic associated acute kidney injury challenging. In addition, only one research paper has included a study population with greater than 50% Black patients.

          Review Article Pages: 1 - 8

          Solid Phase Peptide Synthesis and Its Applications in Tackling Antimicrobial Resistance

          Aditya Prakash Sarode* and Shraddha Dingare

          DOI: 10.37421/2472-1212.2023.9.320

          Solid Phase Peptide Synthesis (SPPS) is a powerful tool for the design and synthesis of peptides with potential antimicrobial activity. In recent years, SPPS has emerged as a promising strategy for the development of new antimicrobial agents. SPPS is a synthetic method that allows for the efficient and rapid production of peptides using solid-phase supports. This technique involves stepwise addition of protected amino acids to a resin-bound peptide chain, followed by deprotection and cleavage to release the desired peptide. The resulting peptides can be modified to enhance their activity, stability, and bioavailability. One of the key advantages of SPPS is its ability to produce peptides with high purity and homogeneity. This is critical for the development of antimicrobial peptides, which require high levels of activity and specificity to target bacterial cells effectively. Additionally, SPPS allows for the production of peptide libraries, which can be screened to identify new antimicrobial agents with improved activity and selectivity. Several studies have demonstrated the effectiveness of SPPS-derived peptides against multidrug-resistant bacteria, including Methicillin-Resistant Staphylococcus aureus (MRSA), Vancomycin-Resistant Enterococcus faecalis (VRE), and Carbapenem-Resistant Klebsiella pneumoniae (CRKP). These peptides have been shown to target bacterial membranes, disrupt cell wall synthesis, and inhibit essential enzymatic processes. In conclusion, SPPS has emerged as a powerful tool for the development of new antimicrobial agents. The ability to rapidly synthesize and modify peptides with high purity and homogeneity has opened up new opportunities for the design of effective therapies against multidrug-resistant bacteria. As the threat of antimicrobial resistance continues to grow, SPPS will play an increasingly important role in the fight against infectious diseases.

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