Reem Rabie Mohammed Salih* and Haytham Hashim Gibreel
M. M El-ajaily*, M. M. Miloud, T. H. Al-noor, R. K. Mohapatra and N. S. Al-barki
A Schiff base (HL1), namely; [(S, Z)-2-((2-hydroxy-1-phenylethylidene) amino)-3-(4-hydroxyphenyl) propanoic acid] was synthesized by the condensation of 2-hydroxyacetophenone with an amino acid (L-Tyrosine) for one hour. Whereas, the other Schiff base (HL2), namely; (E)-4-((2-(2, 4-dinitrophenyl) hydrazono) methyl)-N, N-dimethylaniline] was synthesized by refluxing 4- dimethylaminobenzaldehyde and 2, 4-dinitrophenylhydrazine for one hour. The first Schiff base (HL1) used ad primary ligand and the second one is used as secondary ligand to form five mixed ligand complexes with Co(II), Ni(II), Cu(II), Zn(II) and Fe(III) ions. The synthesized mixed ligand complexes were subjected to several physiochemical techniques, in terms; CHN elemental analyses, molar conductivity, magnetic moments and spectroscopic tools (FT-IR, 1HNMR, electronic, E.P.R and mass spectra). The analytical and spectroscopic data showed the presence of an octahedral geometry for all the mixed ligand complexes. The free Schiff bases, metal salts and mixed ligand complexes were tested for their antifungal activities on some pathogenic fungi species [A. niger, A. flavus, Alternaria alternata, Rhizopus stolonifer].
Andrew A Yabusaki*
The selection of inpatient empiric antibiotic regimens is a significant challenge for hospitalists and clinicians today. Much is known about the increased incidence of acute kidney injury associated with the use of vancomycin and piperacillin-tazobactam in combination compared to vancomycin and other beta-lactam combinations. What is less clear is the incidence of antibiotic associated acute kidney injury and outcomes in Black patients. Incidence rates of acute kidney injury are already known to be higher in Black patients compared to white patients, which makes extrapolating the risks of antibiotic associated acute kidney injury challenging. In addition, only one research paper has included a study population with greater than 50% Black patients.
DOI: 10.37421/2472-1212.2023.9.289
Aditya Prakash Sarode* and Shraddha Dingare
DOI: 10.37421/2472-1212.2023.9.320
Solid Phase Peptide Synthesis (SPPS) is a powerful tool for the design and synthesis of peptides with potential antimicrobial activity. In recent years, SPPS has emerged as a promising strategy for the development of new antimicrobial agents. SPPS is a synthetic method that allows for the efficient and rapid production of peptides using solid-phase supports. This technique involves stepwise addition of protected amino acids to a resin-bound peptide chain, followed by deprotection and cleavage to release the desired peptide. The resulting peptides can be modified to enhance their activity, stability, and bioavailability. One of the key advantages of SPPS is its ability to produce peptides with high purity and homogeneity. This is critical for the development of antimicrobial peptides, which require high levels of activity and specificity to target bacterial cells effectively. Additionally, SPPS allows for the production of peptide libraries, which can be screened to identify new antimicrobial agents with improved activity and selectivity. Several studies have demonstrated the effectiveness of SPPS-derived peptides against multidrug-resistant bacteria, including Methicillin-Resistant Staphylococcus aureus (MRSA), Vancomycin-Resistant Enterococcus faecalis (VRE), and Carbapenem-Resistant Klebsiella pneumoniae (CRKP). These peptides have been shown to target bacterial membranes, disrupt cell wall synthesis, and inhibit essential enzymatic processes. In conclusion, SPPS has emerged as a powerful tool for the development of new antimicrobial agents. The ability to rapidly synthesize and modify peptides with high purity and homogeneity has opened up new opportunities for the design of effective therapies against multidrug-resistant bacteria. As the threat of antimicrobial resistance continues to grow, SPPS will play an increasingly important role in the fight against infectious diseases.
DOI: 10.37421/2472-1212.2023.9.299
DOI: 10.37421/2472-1212.2023.9.300
Amira S Shafaay*, Ebtesam E Ateia, MK Abdelamksoud and MM Arman
DOI: 10.37421/2472-1212.2023.9.319
CoEr0.0.25Fe1.975O4, CoFe2O4/0.1GR, and CoEr0.0.25Fe1.975O4/0.1GR nanoparticles were synthesized by using citrate auto combustion technique. The structure, morphology, magnetic and thermo-electrical properties of obtained nanocomposites have been examined using the Xray diffraction technique, Fourier-Transform Infrared Spectroscopy (FT-IR), high-resolution transmission electron microscopy and vibrating sample magnetometer. Introducing graphene into the CoFe2O4 decreases the particle size and increases the magnetization of the system. The increase in the magnetic moment and hence the saturation magnetization can be attributed to the grafting of functional groups or adatoms to the graphene planes or to the edge bonds. The main mechanism of adatom chemisorption on graphene is breaking the π bonds and producing an additional σ bond. While dual doping with rare earth Er3+/graphene decreases the saturation magnetization of the composites from 70.336 to 36.285 emu/g. However, the decrease in all magnetic parameters for CoEr0.025Fe1.975O4/0.1GR can be attributed to the doping of rare earth ions (Er3+) that decreases the parallelism between the magnetic moments at the B site. This decrease offsets to some extent the increase of unpaired spins resulting due to the addition of graphene.
The application of the thermoelectric concept will help to deal with two main global issues, the increasing demand for energy with all the developments and the drastic climate changes. Consequently, the Seebeck coefficient as a function of temperature is scrutinizing. Graphene is one of the main issues for increasing the efficiency of antibacterial activity. It is obvious that the CoFe2O4/0.1GR sample has a strong antibacterial activity against Pseudomonas aervginosa.
DOI: 10.37421/2472-1212.2025.11.387
In the relentless battle against microbial threats, the emergence of drug-resistant strains poses a formidable challenge to global health. Traditional drug discovery methods are time-consuming, expensive, and often yield limited success. The integration of artificial Intelligence (AI) in drug discovery has opened new frontiers in the quest for effective antimicrobial agents. This article explores the pivotal role that AI plays in revolutionizing the drug discovery process, accelerating the identification of novel antimicrobial compounds, and addressing the urgent need for innovative solutions in the face of evolving microbial resistance.
Baidaa M. Kadim* and Haider S. Abdulhusein
The hides and skins are contaminated by bacteria that are found in the atmosphere, soil, water, dung, and slaughterhouses. Prior investigations have discovered antibiotic-resistant gam-positive and gram-negative bacteria in both the liquids used for soaking and the hides that were soaked, despite the use of several antimicrobial agents during the soaking process. Optimal concentration of the antimicrobial agent is essential to ensure the soaking process is carried out efficiently and effectively. Hence, it is feasible to control bacterial contamination on the skin. This study aimed to investigate the Minimum Inhibitory Concentrations (MICs) of antimicrobial agents containing three different chemical materials: Thiocyanomethylthiobenzothiazole, potassium dimethyldithiocarbamate, and benzyloxymethanol. Each of these active ingredients was tested separately at different concentrations against gram-positive bacteria, including Staphylococcus haemolyticus, Staphylococcus taiwanensis, Staphylococcus aureus, Staphylococcus epidermidis, Peribacillusfrigoritolerans, Bacillus haynesii, Bacillus piscis, and Corynebacterium aurimucosum. Also against gram-negative bacteria Pseudomonas iranica and Pseudomonas oryzihabitans, those were previously obtained from leather industry. In addition, to assess the susceptibility of these isolates to eight different antibiotics: Cefotaxime (5 μg), Amikacin (30 μg), Spectinomycin (100 μg), Tetracycline (30 μg), Rifampicin (5 μg), Cephalothin (30 μg), Sulbactam/ Ampicillin (10 μg), and Neomicin (30 μg). The Kirby-Bauer disc diffusion susceptibility test method was employed on Mueller Hinton agar. In addition, this investigation utilized 22 different doses of antimicrobial chemicals that had three different active components. The concentrations ranged from 2500 μg/ml to 0.001 μg/ml for thiocyanomethylthiobenzothiazole, 5000 μg/ml to 0.002 μg/ml for potassium dimethyldithiocarbamate, and 10000 μg/ml to 0.0047 μg/ml for benzyloxymethanol as the active ingredient. The results found that the growth of all tested isolates was inhibited after exposure to the concentrations of antimicrobial agents containing thiocyanomethylthiobenzothiazole as an active ingredients started from 2500 μg/ml to 39.06 μg/ml, 5000 μg/ml to 156.25 μg/ml containing potassium dimethyldithiocarbamate, and 1000 μg/ml to 312 μg/ml containing benzyloxymethanol. This investigation will be useful if it shares with industries.
Journal of Antimicrobial Agents received 444 citations as per Google Scholar report
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