Clinical Immunology Research Articles

Over the past decade, immuno-oncology (I-O) has become an exciting area of personalized medicine due to its enormous potential to harness the body's immune system to fight cancer. The basis of I-O is that the immune system can recognize and eliminate tumors through the immunosurveillance process.

Immunotherapy is used to fight diseases such as cancer by stimulating or strengthening the immune system of patients or by giving proteins from the artificial immune system to attack cancer cells. Certain types of cancer respond well to immunotherapy treatment alone while other cancers respond better when used in combination with other types of treatment such as chemotherapy.

Types of cancer immunotherapy include:
• Monoclonal antibodies (mAbs) are modified proteins that target tumor-associated antigens, which in turn evokes an immune response to kill cancer cells
• Checkpoint inhibitor therapy targets immune “checkpoints”, key regulators of the immune system that cancer cells use to their advantage to protect themselves from attacks by the immune system. Cancer cells can often escape detection by interfering with these checkpoints on immune cells, especially T lymphocytes. This type of therapy, usually based on antibodies, essentially removes the "brakes" from the immune system and restores immune function by recognizing and destroying cancer cells. There are several checkpoint targets, including PD-1 and CTLA-4, which are found on T cells and PD-L1, on cancer cells.
• Cytokines such as interferon interfere with the growth and multiplication of cancer cells, stimulate the immune system, and encourage cancer cells to produce chemicals that cause an immune response.
• Adoptive cell transfer such as chimeric antigen receptor (CAR-T) cell therapy in which the patient's T cells are extracted, genetically modified and transferred back to the patient so that these altered cells can now recognize and attack cancer cells.

High Impact List of Articles

Multiple Endocrine Neoplasia Type 1 Presenting with Hypoglycemia due to Insulinoma: A Case Report
Husain Taha Radhi, Riyadh Almerbati, Ebtihal Al Yusuf, Rawdha Fardan, Hasan Farooq and Saeed Khalaf
Case Report: Journal of Immunobiology
Multiple Endocrine Neoplasia Type 1 Presenting with Hypoglycemia due to Insulinoma: A Case Report
Husain Taha Radhi, Riyadh Almerbati, Ebtihal Al Yusuf, Rawdha Fardan, Hasan Farooq and Saeed Khalaf
Case Report: Journal of Immunobiology
Immune Response Profile in Susceptibility and Protection in Visceral Leishmaniasis
Jacqueline A Fiuza and Soraya T Gaze
Review Article: Journal of Immunobiology
Immune Response Profile in Susceptibility and Protection in Visceral Leishmaniasis
Jacqueline A Fiuza and Soraya T Gaze
Review Article: Journal of Immunobiology
Association between Vitiligo and Thyroid Autoimmunity in Jordanian Population
Alawneh S, Ayman Abu Awad , Mamoon Athamneh , Salim Abdelrahman, Mohammad Abu-Zaid, Omema D Abu-Alsondos and Nedal Alnawaiseh
Research Article: Journal of Immunobiology
Association between Vitiligo and Thyroid Autoimmunity in Jordanian Population
Alawneh S, Ayman Abu Awad , Mamoon Athamneh , Salim Abdelrahman, Mohammad Abu-Zaid, Omema D Abu-Alsondos and Nedal Alnawaiseh
Research Article: Journal of Immunobiology
Resistance of Bacteria to the Factors of the Innate Immune System, Mediated by Bacterial Proteases
Tyurin YA and Mustafin IG
Review Article: Journal of Immunobiology
Resistance of Bacteria to the Factors of the Innate Immune System, Mediated by Bacterial Proteases
Tyurin YA and Mustafin IG
Review Article: Journal of Immunobiology
In ovo and Dietary Supplementation of Probiotics Affects Post-Hatch Expression of Immune-Related Genes in Broiler Chicks
Chasity M Pender, Sungwon Kim, Lindsay H Sumners, Miranda M Ritzi, Mark Young and Rami A Dalloul
Research Article: Journal of Immunobiology
In ovo and Dietary Supplementation of Probiotics Affects Post-Hatch Expression of Immune-Related Genes in Broiler Chicks
Chasity M Pender, Sungwon Kim, Lindsay H Sumners, Miranda M Ritzi, Mark Young and Rami A Dalloul
Research Article: Journal of Immunobiology

Conference Proceedings

Is only reduction in CD4 Count responsible for secondary infections seen in HIV patients ?
Rajeev Shah
Keynote: Medical Microbiology & Diagnosis
Is only reduction in CD4 Count responsible for secondary infections seen in HIV patients ?
Rajeev Shah
Keynote: Medical Microbiology & Diagnosis
Cenoantibiogram: A biotechnological application for the evaluation of antibiotic resistance of mouse gut microbiota subjected to infection with influenza virus
Marina Robas
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Cenoantibiogram: A biotechnological application for the evaluation of antibiotic resistance of mouse gut microbiota subjected to infection with influenza virus
Marina Robas
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Screening of carbohydrate-utilizing bacteria as a new probiotic candidate for development of Thaipigmented rice probiotic products
Saran Promsai, Thapakorn Chumphon, Papitchaya Silapavanich, Boonthida Boonsiri and Sujinan Meelai
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Screening of carbohydrate-utilizing bacteria as a new probiotic candidate for development of Thaipigmented rice probiotic products
Saran Promsai, Thapakorn Chumphon, Papitchaya Silapavanich, Boonthida Boonsiri and Sujinan Meelai
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Quorum sensing inhibition may mediate anti-microbial efficacy of Quellthera EPQ-100 botanical drug candidate against multi-drug resistant ESKAPE pathogens
Kiran H Bijlani, Rowena Matias, Ana Najafi, Ron Najafi and Sridhar Arumugam
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Quorum sensing inhibition may mediate anti-microbial efficacy of Quellthera EPQ-100 botanical drug candidate against multi-drug resistant ESKAPE pathogens
Kiran H Bijlani, Rowena Matias, Ana Najafi, Ron Najafi and Sridhar Arumugam
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Prevalence of heavy metal and multiple antibiotic resistances in bacterial species isolated from Hasdeo River water
Rajshree Singh and Shweta Sao
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Prevalence of heavy metal and multiple antibiotic resistances in bacterial species isolated from Hasdeo River water
Rajshree Singh and Shweta Sao
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis

Journal of Immunobiology