Journal of Immunobiology

Pamela C Gibson

Publications

• Case Report
  Development of de novo Hemolytic Uremic Syndrome Post-Transplant and the Role of Donor Specific Antibodies: A Case Report and Review of Literature
  Author(s): Sean M Wrenn, Pamela C Gibson, Donna-Sue Hain, Sarah Harm, Paulette B Hammond, Diti H Shah, Susan E Hillyard, Mark Fung and Carlos E MarroquinSean M Wrenn, Pamela C Gibson, Donna-Sue Hain, Sarah Harm, Paulette B Hammond, Diti H Shah, Susan E Hillyard, Mark Fung and Carlos E Marroquin
  
  Introduction: Hemolytic uremic syndrome (HUS) following kidney transplantation is a devastating complication that may result in substantial morbidity and allograft loss. While calcineurin inhibitor-induced HUS has been well described, anti-donor specific antibody production may be an alternative pathway in the pathogenesis of HUS. We present a case of HUS following kidney transplantation, and will present evidence that donor specific antibodies (DSA) may be a factor in platelet activation and end-organ injury resulting in post-transplant HUS. Case Description: A 66-year-old female with diabetic nephropathy underwent a deceased donor renal transplant with a 5 HLA mismatched kidney. Her immediate course was uneventful with normalization of her creatinine (Cr). She was re-admitted with rising Cr, oliguria, proteinuria, anaemia and thrombocytopenia. A peripheral smear revealed schistocyte.. Read More»
  DOI: 10.4172/2476-1966.1000101

  Abstract PDF