Chalcone-derived lactones have garnered significant attention for their diverse pharmacological properties, including antibacterial and antifungal activities. In this study, we present a comprehensive synthesis of novel chalcone-derived lactones and employ whole-cell biotransformation techniques to enhance their bioavailability. The antibacterial and antifungal potential of these transformed compounds is evaluated against a panel of clinically relevant pathogens. Our findings reveal promising antimicrobial activity, highlighting the potential of chalcone-derived lactones as a valuable class of compounds for the development of novel therapeutics.
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Journal of Food & Industrial Microbiology received 160 citations as per Google Scholar report
