Translational Immunology Scholarly Journals

Translational immunology is the process by which researchers use immunological discoveries to develop practical solutions to human problems. Examples include the development of vaccines against infectious diseases or the engineering of new types of drugs to treat inflammatory disorders.

Spontaneous responses to anti-tumor T cells in cancer patients are strongly controlled by Tregs, and an increase in the number of Tregs infiltrating tumors is correlated with reduced survival. However, the tumor antigens recognized by Tregs in cancer patients and the impact of these cells on the responses of tumor-specific T lymphocytes have not been systematically characterized. Here, we have used a large panel of long synthetic peptides of defined tumor antigens and normal tissue antigens to exploit a newly developed method to identify and compare ex vivo the antigenic specificities of Tregs with those of effector / memory T lymphocytes in the peripheral blood of colorectal cancer patients and healthy subjects. Tregs in patients with tumors were highly specific for a distinct set of only a few tumor antigens, suggesting that Tregs selectively antigen suppress T cells. Tumor specific effector T cells were detectable in the majority of colorectal cancer patients but not in healthy individuals. We detected differences in the repertoires of antigens recognized by Treg and effector / memory T lymphocytes in the majority of patients with colorectal cancer. Furthermore, only the effector / memory T lymphocyte responses against the antigens recognized by the Tregs increased sharply after the Treg depletion. Selecting antigens based on pre-existing T cell responses could improve the effectiveness of future immunotherapies against cancer and autoimmune diseases.

High Impact List of Articles

Conference Proceedings

Looking back the years of the biotech revolution
Daniele Palmisani
Scientific Tracks Abstracts: Medical Microbiology & Diagnosis
Looking back the years of the biotech revolution
Daniele Palmisani
Scientific Tracks Abstracts: Medical Microbiology & Diagnosis
Pseudomonas biofilm, swarming motility and biocides resistance
Meliani Amina and Douad Yousra
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Pseudomonas biofilm, swarming motility and biocides resistance
Meliani Amina and Douad Yousra
Posters & Accepted Abstracts: Medical Microbiology & Diagnosis
Development and formulation of liposome encapsulated silver nanoparticles and tea tree oil for skin infections
Ashraf O Abdellatif and Suad Y Alkarib
Scientific Tracks Abstracts: Medical Microbiology & Diagnosis
Development and formulation of liposome encapsulated silver nanoparticles and tea tree oil for skin infections
Ashraf O Abdellatif and Suad Y Alkarib
Scientific Tracks Abstracts: Medical Microbiology & Diagnosis
Severe outcome in influenza virus infected patients is associated with reduced accumulation of defective viral genomes
Ana Falcon
Keynote: Medical Microbiology & Diagnosis
Severe outcome in influenza virus infected patients is associated with reduced accumulation of defective viral genomes
Ana Falcon
Keynote: Medical Microbiology & Diagnosis
Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated from different hospitals in Kathmandu Valley
Sagar Aryal, Sunil Lekhak and Pramila Parajuli
Scientific Tracks Abstracts: Medical Microbiology & Diagnosis
Molecular characterization of multidrug-resistant Mycobacterium tuberculosis isolated from different hospitals in Kathmandu Valley
Sagar Aryal, Sunil Lekhak and Pramila Parajuli
Scientific Tracks Abstracts: Medical Microbiology & Diagnosis

Journal of Immunobiology