GET THE APP
Antibiotics Acting On The Ribosome | Open Access Journals
Journal of Antimicrobial Agents

Journal of Antimicrobial Agents

ISSN: 2472-1212

Open Access
Spanish Chinese Russian German French Japanese Portuguese Hindi Telugu Tamil
Submit Manuscript arrow_forward arrow_forward ..

Antibiotics Acting On The Ribosome

The binding of antibiotics to the ribosome is a prerequisite for their action. Most studies on the binding of antibiotics (A) to the ribosome (R) have so far been based on the assumption that this interaction can be expressed by a rapid equilibrium of the form R + A RA, by putting l focus on thermodynamic interaction control. Bacteria have developed several elegant solutions to rid the ribosome of antibiotics, for example, by lowering the intracellular A concentration by pumping antibiotics and preventing their absorption, or by increasing the dissociation of the RA complex by reprogramming the target structure [6] and by destroying the antibiotic warhead. Consequently, efforts to develop new antibiotics have often been directed towards approaches tending to exploit the thermodynamic control of the antibiotic-ribosome interaction, thus neglecting the kinetic control of the binding process.

High Impact List of Articles
Conference Proceedings

Relevant Topics in Immunology & Microbiology

Awards & Nominations

50+ Million Readerbase

Journal Highlights

Google Scholar citation report
Citations: 444

Journal of Antimicrobial Agents received 444 citations as per Google Scholar report

Citation image
Journal of Antimicrobial Agents peer review process verified at publons
Publon image

Indexed In

Related Links

 

Open Access Journals

arrow_upward arrow_upward