Andrea Burioli, Enza Cestone, Eleonora Spartà, Manuela Sciumè, Vincenzo Zaccaria, Violetta Insolia and Vincenzo Nobile*
DOI: 10.37421/2471-9323.2023.9.201
The skin sensitive syndrome is a widespread condition with an impact on the quality of life of the affected subjects. Cosmetics may be formulated specifically for sensitive skin conditions, alleviating the relative symptoms. The present study aimed at evaluating the efficacy of a natural extract containing polysaccharides from Opuntia ficus-indica (cladodes extract), biophenols from Olea Europaea (olive leaves extract) and flavonoids from Capparis spinosa (caper fruit) on skin discomfort induced by different stressors such as skin redness and skin barrier function alteration by shaving/ epilation; neurogenic mediated by capsaicin; and skin redness induced by UV exposure. Three randomized double-blind, controlled studies were carried out on 20 Caucasian subjects. Product efficacy was measured by means of both instrumental measures (redness and transepidermal water loss, TEWL) and by subjective scoring of the functional signs (itching/stinging and burning sensations) induced by each stressor. The active ingredient showed to decrease: the skin redness and the TEWL after shaving/epilation, the capsaicin-induced skin discomforts and the UV-induced skin redness. Our results demonstrate the ingredient efficacy in decreasing the skin discomforts induced by physical, chemical and environmental agents. The soothing and protective activities besides this cosmetic ingredient might be used in formulations for sensitive skin condition management.
Enza Cestone, Eleonora Spartà, Vincenzo Nobile*, Vincenzo Zaccaria*, Francesco Pappalardo, Violetta Insolia, Giuseppe Antonio Malfa, Daniela Buonocore and Maurizia Dossena
DOI: 10.37421/2471-9323.2023.9.207
Androgenetic Alopecia (AGA) is a progressive hair loss type affecting up to 80% of men and 50% of women. The putative mechanisms in the pathogenesis of AGA include microinflammation, premature cell senescence, oxidative stress, follicle vascular changes and altered sensitivity of hair follicles to androgens. A randomized, double-blind, placebo-controlled trial was carried out on 86 male subjects with AGA from II to III vertex (Hamilton-Norwood). Product efficacy was measured after 3, 6 months of product intake and 1-month post-supplementation. The hair cycle parameters measurement by phototricogram were integrated by the global photography assessment and the self-assessment questionnaire. The results showed an increase of the total hair density and the % of hair in anagen phase with a simultaneous decrease in the % of hair in telogen phase; as consequence the anagen/telogen ratio was improved of about 45.7% and 85.8% at 3 and 6 mo, respectively. The instrumental data were confirmed by the clinical analysis carried out by a board-certified dermatologist and by the self-assessment questionnaire. The obtained improvements were also maintained 1-month post-supplementation. The intake of 250 mg of ActrisaveTM improved the hair life cycle increasing hair growth, density and slowing down hair loss in men with mild-to-moderate androgenetic alopecia.
DOI: 10.37421/2471-9323.2023.9.208
DOI: 10.37421/2471-9323.2023.9.214
DOI: 10.37421/2471-9323.2023.9.213
DOI: 10.37421/2471-9323.2023.9.215
DOI: 10.37421/2471-9323.2023.9.212
Integrating exploration and scholarly pursuits into the calling of dermatology is essential for advancing the field, improving patient care and fostering professional development. Dermatologists have the opportunity to engage in research, scholarly writing, continuing education and teaching to expand knowledge, refine clinical skills and contribute to the advancement of dermatology. By participating in research, dermatologists can generate new knowledge, improve diagnostic and treatment approaches and provide evidence-based guidance. Scholarly writing allows dermatologists to share expertise, influence clinical practice and gain recognition within the field. Continuing education ensures that dermatologists stay updated with emerging trends and advancements, while academic involvement and teaching activities contribute to the growth of the field and shape the next generation of dermatologists. The integration of exploration and scholarly pursuits in dermatology leads to the advancement of the field, enhanced clinical practice, professional growth and opportunities for networking and collaboration. Embracing academic involvement enriches dermatologists' careers, positively impacts patient outcomes and cultivates a culture of lifelong learning in dermatology.
DOI: 10.37421/2471-9323.2023.9.211
DOI: 10.37421/2471-9323.2023.9.210
DOI: 10.37421/2471-9323.2023.9.209
Dermatology associations play a crucial role in advancing the field of dermatology, providing opportunities for professional development, networking and advocacy. The variety of associations available caters to specific interests and demographics, creating a diverse and supportive community for dermatologists. These associations offer valuable resources, including educational programs, networking platforms, research publications and professional support, enabling dermatologists to enhance their skills, stay updated with advancements and contribute to their respective fields. However, when considering participation in dermatology associations, dermatologists should carefully evaluate the relevance to their professional goals, financial considerations, time commitments and the reputation and credibility of the associations. Active engagement in dermatology associations fosters innovation, collaboration and excellence in the field, benefiting dermatologists and patients alike
Abbas Mohammadi
Plexr is the latest technology for Blepharoplasty and Non Invasive Eye Lid Surgery. Limited studies have been done on this technique and so far no side effects have been reported. For the first time in this study, we will describe 3 patients with complaints after Plasma Exeresis (Plexr). Here the authors present 3 patients that presented to the authors institution over a 5-month period with complaints after Plasma Exeresis (Plexr). Complaints included upper lid skin burns, severe eyelid swelling and erythema, and Postinflammatory hyperhypopigmentation eyelid lesion and unhealing dermatochalasia. In this report we discuss the clinical presentations, diagnostic evaluation, treatment options, and clinical outcomes as they relate to Complications of Noninvasive Upper Lid Blepharoplasty (Plasma Exeresis (Plexr)).
Elena E. Pakhomova
The article deals with the use of platelet-rich plasma in the treatment of androgenetic alopecia: effectiveness, problems and prospects. Androgenetic Alopecia (AGA) is one of the most common types of non-scarring hair loss. Baldness affects the psycho-emotional state of a person, which significantly reduces the quality of life. An opinion deviating from generally accepted standards exists that with a normal level of androgens in the blood, AGA in men is a normal biological phenomenon, and not a disease. Regardless of how their condition is classified, people with AGA perceive it as a deviation from the norm, unacceptable from a psychosocial point of view, and turn to a doctor for treatment.
Alpana Mohta
Congenital melanocytic nevi with a diameter of at least 10 cm or covering 1% body surface area on the face/head/neck or 2% on rest of the body at any age, and by an extetension those least 6 cm on the trunk and 9 cm on the head in a neonate are known as giant congenital melanocytic nevus (GMNC). Although, a rare entity they may pose possible risk of malignancy and neurocutaneous melanosis, apart from cosmetic concerns. The psychosocial distress posed by them has also been studied extensively by many authors. On histopathological analysis epitheloid lymphocytoid and neuroid nevus cells can be visualized. Owing to such myrid presentations the management option for GCMN has to be tailored to every patient. There is a common consensus that prophylactic removal of a GCMN has little to no advantage. The partial debulking of a GCMN can be done by mechanical or chemical exfoliation, currete, shave excision or laser therapy. However, in view of potential risk of malignancy total or subtotal deep excision followed by plastic reconstruction must be considered, especially in cases involving the head and neck area.
Sayo Kashiwagi
Objective: Topical application of minoxidil has been adopted as an effective treatment for male and female pattern hair loss. While higher concentration formulas exhibit better efficacy, dissolving and stabilizing minoxidil is technically challenging. L-(+)-Tartaric Acid (LTA) is a colorless crystalline dicarboxylic acid found in plants and has been used as an additive in various hair care products to stabilize the biological functions of active ingredients. LTA has been added to minoxidil to maintain the quality of over-the-counter formula. To date, the influence of LTA on human Hair Follicle (HF) cells has not been sufficiently investigated. As the Dermal Papilla (DP) plays pivotal roles in the regulation of HF regeneration and the hair cycle, we aimed to elucidate the effects of LTA on human Dermal Papilla cells (hDPCs). Methods: hDPCs were first subject to cytotoxicity and alkaline phosphatase assay after treated LTA. Microarray comparison analysis was performed to elucidate LTA effects on global gene expression on LTA-treated and non-treated hDPCs. Subsequent real-time polymerase chain reaction analysis using multiple donor-derived hDPCs was done to further confirm LTA-induced hair growth genes up-regulation. Results: LTA exhibited no influence on hDPCs in a cytotoxicity assay. The activity of a representative hDPC marker enzyme, alkaline phosphatase, was not impaired by LTA in cultured hDPCs. Microarray comparison analysis of LTA-treated and non-treated hDPCs elucidated that LTA minimally affected the molecular signature of hDPCs but, intriguingly, up-regulated some hair growth-related genes. Subsequent real-time polymerase chain reaction analysis using multiple donor-derived hDPCs confirmed that LTA indeed increased the gene expression of activin A receptor type 2A (ACVR2A) and Insulin-like Growth Factor Binding Protein 5 (IGFBP5), while down-regulation of hair growth-related genes by LTA was inconsistent among hDPCs derived from respective donors. Conclusion: These results suggest that LTA minimally affects but potentially supports the biological characteristics of hDPCs. LTA may represent a useful additive to generate efficacious, high concentration formula of active reagents, represented by minoxidil.
Tatsiana Pukhalskaya
The differential diagnosis of a lobular panniculitis without vasculitis can be extensive. This review article is based on a case we recently described and is aimed to address the most common variants of lobular panniculitis that could be mistaken for Subcutaneous Panniculitis-Like T-cell Lymphoma (SPTCL). The neoplastic lymphocytes express CD8+ with rearranged an α/β subunit of the T-cell receptor. Cytotoxic markers are always expressed (TIA1, perforin, and granzyme B), but CD56 and CD30 are consistently negative
DOI: 10.37421/2471-9323.2023.9.206
DOI: 10.37421/2471-9323.2023.9.202
Hair loss, also known as alopecia, is a common condition that affects people of all ages and genders. It can have a significant impact on a person's self-esteem and quality of life. Hair loss can be caused by a variety of factors, including genetics, hormonal changes, medical conditions, medications and lifestyle factors. The most common type of hair loss is androgenetic alopecia, which is hereditary and affects both men and women. Other types of hair loss include alopecia areata, which is an autoimmune disorder and telogen effluvium, which is usually caused by stress or illness. Treatment options for hair loss vary depending on the cause and severity of the condition and may include medications, hair transplantation, or lifestyle changes. With proper diagnosis and treatment, many people with hair loss are able to regain some or all of their hair and improve their overall well-being.
DOI: 10.37421/2471-9323.2023.9.204
Androgenetic alopecia is a common type of hair loss that affects both men and women. It is a genetically determined condition that is characterized by a gradual and progressive thinning of the hair on the scalp, eventually leading to baldness in some cases. The condition is caused by a combination of genetic and hormonal factors, with dihydrotestosterone (DHT), a male hormone, playing a key role in its development. DHT can cause hair follicles to shrink, which results in shorter and thinner hair strands over time. Androgenetic alopecia is typically diagnosed based on the pattern of hair loss and the presence of other symptoms, such as itching or scaling of the scalp. Treatment options for androgenetic alopecia include medications, such as minoxidil and finasteride, which can help slow down or even reverse hair loss in some cases. In more severe cases, hair transplantation surgery may be necessary to restore hair growth. While androgenetic alopecia can be distressing, it is important to remember that it is a common condition and there are many effective treatments available to help manage it.
DOI: 10.37421/2471-9323.2023.9.203
DOI: 10.37421/2471-9323.2023.9.205
DOI: 10.37421/2471-9323.2023.9.211
Plastic surgery offers individuals the opportunity to transform their physical appearance and boost their self-confidence. However, the journey of post-plastic surgery extends beyond the operating room, encompassing the physical healing process, emotional adjustments, and personal growth. This article explores the various aspects of post-plastic surgery transformation, including the physical healing process and the emotional challenges individuals may face. It highlights the importance of maintaining realistic expectations, seeking support from loved ones, and practicing self-care. Coping strategies, such as managing discomfort, embracing changes in physical appearance, and handling others' reactions, are also discussed. Embracing a new chapter after plastic surgery involves developing a positive self-image, setting realistic expectations, and celebrating personal growth. By prioritizing self-acceptance, self-love, and surrounding oneself with positive influences, individuals can confidently embrace their new physical appearance and live a fulfilling life. Understanding that plastic surgery is a tool for self-improvement, combined with inner transformation, empowers individuals to embark on a journey of self-discovery and embrace their unique beauty.
DOI: 10.37421/2471-9323.2023.9.212
DOI: 10.37421/2471-9323.2023.9.213
DOI: 10.37421/2471-9323.2023.9.214
DOI: 10.37421/2471-9323.2023.9.215
DOI: 10.37421/2471-9323.2023.9.216
In the ever-evolving world of beauty, cosmetology stands as a time-honored profession, steeped in tradition and expertise. Yet, it operates within a dynamic industry where trends emerge, change and sometimes fade away in the blink of an eye. The delicate balance between the enduring principles of cosmetology and the allure of beauty trends is a topic worth exploring. In this discussion, we delve into the juxtaposition of cosmetology and beauty trends, analyzing how these two elements coexist and influence one another while seeking equilibrium in the pursuit of beauty.
DOI: 10.37421/2471-9323.2023.9.217
Women's health and well-being have seen significant advancements over the years and one area that has gained prominence is cosmetic gynecology. While traditional gynecological care focuses on reproductive health and medical concerns, cosmetic gynecology addresses the aesthetic and functional aspects of a woman's genital region. This article explores the rise of cosmetic gynecology procedures, the motivations behind them and the empowerment they offer to women seeking to enhance their confidence and quality of life.
DOI: 10.37421/2471-9323.2023.9.216
Our skin is not just an outer covering; it's a canvas that reflects our health, beauty and identity. Skin pigmentation plays a significant role in determining our complexion and the uniqueness of our appearance. However, for many individuals, skin pigment disorders such as melasma and hyperpigmentation can be a source of concern. In this exploration, we delve into the intricacies of melasma and hyperpigmentation, shedding light on these skin conditions, their causes, impact and potential solutions. The skin, our body's protective outer layer, is a remarkable canvas that reflects our identity and experiences. It is the stage upon which our diverse hues and tones are showcased, a testament to the intricate interplay of genetics, environment and the fascinating pigment known as melanin. However, this canvas is not always uniform. For many individuals, it bears the marks of hyperpigmentation, a skin condition that can cast shadows on both appearance and self-esteem.
DOI: 10.37421/2471-9323.2023.9.219
Dandruff, with its telltale flakes and persistent itch can be an annoying and sometimes embarrassing condition. Fortunately, there are a plethora of natural remedies that can help alleviate dandruff and provide relief to your scalp without resorting to harsh chemicals or medications. In this guide, we'll explore the causes of dandruff, the effectiveness of natural remedies and provide a comprehensive list of remedies you can try to soothe your scalp and bid farewell to those pesky white flakes.
DOI: 10.37421/2471-9323.2023.9.220
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DOI: 10.37421/2471-9323.2023.9.223
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DOI: 10.37421/2471-9323.2023.9.225
DOI: 10.37421/2471-9323.2023.9.221
Journal of Cosmetology & Trichology received 180 citations as per Google Scholar report
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