Plexr is the latest technology for Blepharoplasty and Non Invasive Eye Lid Surgery. Limited studies have been done on this technique and so far no side effects have been reported. For the first time in this study, we will describe 3 patients with complaints after Plasma Exeresis (Plexr). Here the authors present 3 patients that presented to the authors institution over a 5-month period with complaints after Plasma Exeresis (Plexr). Complaints included upper lid skin burns, severe eyelid swelling and erythema, and Postinflammatory hyperhypopigmentation eyelid lesion and unhealing dermatochalasia. In this report we discuss the clinical presentations, diagnostic evaluation, treatment options, and clinical outcomes as they relate to Complications of Noninvasive Upper Lid Blepharoplasty (Plasma Exeresis (Plexr)).
Elena E. Pakhomova
The article deals with the use of platelet-rich plasma in the treatment of androgenetic alopecia: effectiveness, problems and prospects. Androgenetic Alopecia (AGA) is one of the most common types of non-scarring hair loss. Baldness affects the psycho-emotional state of a person, which significantly reduces the quality of life. An opinion deviating from generally accepted standards exists that with a normal level of androgens in the blood, AGA in men is a normal biological phenomenon, and not a disease. Regardless of how their condition is classified, people with AGA perceive it as a deviation from the norm, unacceptable from a psychosocial point of view, and turn to a doctor for treatment.
Congenital melanocytic nevi with a diameter of at least 10 cm or covering 1% body surface area on the face/head/neck or 2% on rest of the body at any age, and by an extetension those least 6 cm on the trunk and 9 cm on the head in a neonate are known as giant congenital melanocytic nevus (GMNC). Although, a rare entity they may pose possible risk of malignancy and neurocutaneous melanosis, apart from cosmetic concerns. The psychosocial distress posed by them has also been studied extensively by many authors. On histopathological analysis epitheloid lymphocytoid and neuroid nevus cells can be visualized. Owing to such myrid presentations the management option for GCMN has to be tailored to every patient. There is a common consensus that prophylactic removal of a GCMN has little to no advantage. The partial debulking of a GCMN can be done by mechanical or chemical exfoliation, currete, shave excision or laser therapy. However, in view of potential risk of malignancy total or subtotal deep excision followed by plastic reconstruction must be considered, especially in cases involving the head and neck area.
Objective: Topical application of minoxidil has been adopted as an effective treatment for male and female pattern hair loss. While higher concentration formulas exhibit better efficacy, dissolving and stabilizing minoxidil is technically challenging. L-(+)-Tartaric Acid (LTA) is a colorless crystalline dicarboxylic acid found in plants and has been used as an additive in various hair care products to stabilize the biological functions of active ingredients. LTA has been added to minoxidil to maintain the quality of over-the-counter formula. To date, the influence of LTA on human Hair Follicle (HF) cells has not been sufficiently investigated. As the Dermal Papilla (DP) plays pivotal roles in the regulation of HF regeneration and the hair cycle, we aimed to elucidate the effects of LTA on human Dermal Papilla cells (hDPCs). Methods: hDPCs were first subject to cytotoxicity and alkaline phosphatase assay after treated LTA. Microarray comparison analysis was performed to elucidate LTA effects on global gene expression on LTA-treated and non-treated hDPCs. Subsequent real-time polymerase chain reaction analysis using multiple donor-derived hDPCs was done to further confirm LTA-induced hair growth genes up-regulation. Results: LTA exhibited no influence on hDPCs in a cytotoxicity assay. The activity of a representative hDPC marker enzyme, alkaline phosphatase, was not impaired by LTA in cultured hDPCs. Microarray comparison analysis of LTA-treated and non-treated hDPCs elucidated that LTA minimally affected the molecular signature of hDPCs but, intriguingly, up-regulated some hair growth-related genes. Subsequent real-time polymerase chain reaction analysis using multiple donor-derived hDPCs confirmed that LTA indeed increased the gene expression of activin A receptor type 2A (ACVR2A) and Insulin-like Growth Factor Binding Protein 5 (IGFBP5), while down-regulation of hair growth-related genes by LTA was inconsistent among hDPCs derived from respective donors. Conclusion: These results suggest that LTA minimally affects but potentially supports the biological characteristics of hDPCs. LTA may represent a useful additive to generate efficacious, high concentration formula of active reagents, represented by minoxidil.
The differential diagnosis of a lobular panniculitis without vasculitis can be extensive. This review article is based on a case we recently described and is aimed to address the most common variants of lobular panniculitis that could be mistaken for Subcutaneous Panniculitis-Like T-cell Lymphoma (SPTCL). The neoplastic lymphocytes express CD8+ with rearranged an α/β subunit of the T-cell receptor. Cytotoxic markers are always expressed (TIA1, perforin, and granzyme B), but CD56 and CD30 are consistently negative
Paul Clayton*, Ruchitha Venkatesh, Shama, Nathasha Bogoda, Silma Subah and Amanda Rao
Background: Alopecia affects both males and females and can cause significant psychological distress. Ageratum conyzoides, traditionally used to treat a multitude of conditions including skin disorders, gastrointestinal problems, headache and pneumonia, has been also found to have good efficacy in increasing hair growth and decreasing hair loss. Importantly, its good safety profile makes it advantageous over the current drug treatments for hair loss; Finasteride and Minoxidil, both of which are associated with adverse effects.
Objective: A 12-week double-blind, randomised, clinical trial investigated the efficacy and safety of a topical application of A. conyzoides in males and females over 18 years of age.
Methods: A. conyzoides topical gel of 0.5% strength was administered daily for 12 weeks to 80 otherwise healthy males and females over 18 years of age who self-reported hair loss. Hair growth was assessed by measuring hair density using HairCheck® and calculating the Hair Loss Ratio (HLR). Hair loss was assessed by the mean number of hairs lost during a one-minute combing test and a hair tugs or pull test. Other hair measures included the Hamilton-Norwood scale for men and Savin scale for women. Participants' quality of life was evaluated by self-assessment questionnaires. Biochemical and haematological parameters were also assessed.
Results: Our study found a significant increase in hair density and significant decrease in HLR following topical application of A. conyzoides. At 12 weeks, hair density in the A. conyzoides treated group was significantly higher and HLR was significantly lower than the placebo group. No significant changes were found in the one-minute combing test or hair pull test or assessment by the Hamilton-Norwood and Savin hair loss scales. Quality of life measures and biochemical and haematological parameters showed no significant changes throughout the study.
Conclusion: The results from our study demonstrate a net increase in hair growth following topical application of A. conyzoides.
Alopecia areata (AA), despite strong evidence showing its detrimental impact on quality of life (QoL), is frequently viewed by both doctors and insurance as a cosmetic issue. The Cumulative Life Course Impairment (CLCI) concept tries to define the cumulative consequences of sickness that prevent certain individuals from realising their "full life potential." It can help doctors identify high-risk individuals to encourage early intervention and increase access to therapy as an alternative to longitudinal data.
Due of skin damage from their jobs, hairdressers are a high-risk category for occupational skin illnesses. Therefore, hand dermatitis is the most common OSD. Hairdressers had a pooled lifetime incidence of HE of 38.2 percent and a 1-year prevalence of 20.3 percent, according to a recent systematic review and metaanalysis of published material from 2000–2021. The most important variables in the development of HE in this occupational field are wet work and skin contact with irritants and allergens. Numerous primary components in numerous hair cosmetics are serious allergies. The likelihood of getting occupational contact dermatitis increases due to the loss of the epidermal barrier function caused by the typical work practises of hairdressers and the emergence of an inflammatory environment.
Platelet rich plasma (PRP) was depicted as a little volume of plasma containing higher convergences of platelets than those tracked down in fringe blood and at first utilized as a bonding item for treatment of thrombocytopenia. Until now, it was found that there are a few development elements and cytokines that can speed up injury recuperating and tissue recovery, prompting a more extensive scope of uses in the clinical field, for example, in sport medication, regenerative medication and tasteful medication. A few investigations have demonstrated the way that PRP can be utilized really for treatment of balding. In spite of the fact that it has been broadly utilized, the specific component of activity of PRP is as yet not completely clarified. In this article, we mean to survey and refresh current data on the definition, arrangement, system of activity, clinical viability in hair regrowth and unfriendly occasions of PRP.
Oral finasteride is a wellestablished treatment for men with androgenetic alopecia (AGA), but patients do not always tolerate longterm therapy. A topical finasteride formulation has been developed to reduce systemic exposure by targeting hair follicles specifically. To compare the efficacy and safety of topical finasteride to placebo, as well as the systemic exposure and overall benefit to oral finasteride. This 24-week randomised, doubleblind, doubledummy, parallelgroup study in adult male outpatients with AGA was conducted at 45 sites across Europe. The efficacy and safety of the treatment were assessed. Finasteride, testosterone and dihydrotestosterone (DHT) levels were determined.
The lack of suitable EEG electrodes for hairy sites is one of the main obstacles to daily wearable electroencephalogram (EEG) monitoring. Wet anodes require conductive gels, which will dry over the procurement time, making them shaky for long haul EEG checking. Additionally, the majority of dry electrodes' electrode–scalp impedances are insufficient for high-quality EEG collection at hairy locations. This study proposes a flexible multi-layer semi-dry electrode for EEG monitoring in light of the aforementioned issues. A reservoir layer, a foam layer, and a flexible electrode body layer make up the semi-dry electrode. The body layer of the electrode has a probe structure that lets the electrode work well at hairy locations. Electrolytes stored in the reservoir layer are continuously released through the foam layer to the electrode–scalp interface during long-term EEG monitoring, resulting in a lower contact impedance between the electrode and the scalp. The semi-dry electrode performed well in both static and dynamic EEG monitoring, where the temporal correlation with wet electrode signals at the hairy site could reach 94.25% and 90.65%, respectively, and specific evoked EEG signals could be collected. The experimental results showed that the average electrode–scalp impedance of the semidry electrode at a hairy site was only 23.89 7.44 K at 10 Hz, and it was less than 40 K over a long-term use of 5 The multi-layer, flexible semi-dry electrode is a promising option for daily, long-term monitoring of wearable EEGs at hairy locations on the scalp.
Seborrheic Dermatitis (SD) and dandruff are of a consistent range of the very illness that influences the seborrheic region of the body. Dandruff only affects the scalp and is characterized by itchy, flaking skin with no obvious inflammation. The scalp and other seborrheic areas can be affected by SD, which causes pruritus, inflammation, itching, scaling and flaking of the skin. The pathogenesis of SD and dandruff is influenced by a variety of intrinsic and environmental factors, including sebaceous secretions, skin surface fungal colonization, individual susceptibility and interactions between these factors. We present a summary of the most recent information regarding SD and dandruff, including epidemiology, disease burden, clinical manifestations and diagnosis, treatment, genetic studies in human and animal models and risk factors. In animal models, genetic and biochemical research provides additional insight into the pathophysiology and treatment strategies.
Journal of Cosmetology & Trichology received 148 citations as per Google Scholar report