Journal of Dermatology and Dermatologic Diseases

ISSN: 2684-4281

Open Access

Eleonora Da Pozzo


  • Special Issue Article
    Topical Agents for Melasma: A Perspective on Therapeutic Approaches and their Molecular Bases
    Author(s): Eleonora Da Pozzo and Claudia MartiniEleonora Da Pozzo and Claudia Martini

    Melasma is a common skin disease involving changes in normal skin pigmentation. It results from epidermal melanocyte hyperactivity that causes increased production and accumulation of melanin. The onset of the disease has been associated with sun exposure, drugs, genetic and hormonal factors. The primary focus of this review was to provide an updated overview of the main biological aspects behind skin pigmentation and melasma development. As a second aim of this review, the main mechanisms by which different compounds could reduce melanogenesis were also discussed. Common hypo-pigmenting agents act by reducing the melanogenesis through several mechanisms; they can affect melanin transcription and glycosylation, inhibit tyrosinase (a pivotal enzyme in melanin synthesis), slow the melanosome transfer or increase the skin turnover. Although a number of skin-lightening agents were .. Read More»
    DOI: 10.4172/2376-0427.1000S1006

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