Charles J Malemud

Department of Medicine, Division of Rheumatic Diseases, Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, Cleveland, USA

Biography

Dr. Charles J Malemud hails from the department of Medicine, Division of Rheumatic Diseases, Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center, Cleveland, USA. His research group studies the activation of the JAK/STAT signalling pathway by pro-inflammatory cytokines relevant to the pathogenesis and progression of human rheumatoid arthritis and osteoarthritis. They were particularly interested in the extent to which activated STAT proteins are involved in the regulation of matrix metalloproteinase gene expression in normal chondrocytes, chondrocytes derived from rheumatoid arthritis cartilage, osteoarthritic cartilage and in immortalized chondrocytes.