Journal of Immunobiology

Cancer immunotherapy has branched into various categories, and one of the most promising and also frustrating approaches is cancer vaccination. Vaccination has saved a million lives in the world. However, Cancer Vaccine technology has gone a long and challenging way to reach today’s place. A lot of failures in this therapy, galvanized scientists to find more efficient methods for better targeting and precise antigen and adjuvant selection. Divergent platforms and various vaccine types have been tested during the last thirty years. Dendritic Cells, Long/Short peptides, whole tumor cell lysate, viral-based, and Genetic-based vaccines are the most common vaccine types. Novel approaches in cancer vaccination are mainly based on personalized vaccination, Nano-carrier usage, and combination therapy. Moving from TAAs to Neoantigens made scientists achieve more immunogenic vaccines and transferring from bare antigen usage into Nano-/micro- vaccine platforms provided scientists with better targeting and localized vaccines. Also, progresses in the biomaterial field pave the way for developing a more functional vaccine. In this review paper, main vaccine types and novel strategies in cancer vaccine production have been briefly discussed.

Antibody based targeted therapy has considered more than other immunotherapeutic methods for cancer treatment due to extensive capacity of antibodies for targeting specific antigens. Antibodies and antibody fragments can target particular antigens that are expressed by cancer cells and lead them to apoptosis. However, conjugation of antibodies to cytotoxic agents such as drugs, radionuclides, and toxins improves the efficacy of antibody-based targeted therapy. The use of antibodies as carriers to deliver cytotoxic agents to the target cells has led to the emergence of immunoconjugates. The immunoconjugates not only are more effective than naked antibodies but also prevent the side effects of cytotoxic agents by delivering them only to the target cells. Targeted therapy has received more attention due to its fewer side effects on normal cells. This review provides a brief definition of various antibody therapies which are in development and in clinical use for different cancers treatment, as well as describes the mechanism of action of each method.

To get best advantage out of this development, we encourage more types of articles besides, regular research, review or commentary articles we are also planning to publish video article, which is bit interesting. This will help us in scoring high in performance measures and moving up in journal ranking lists. We endeavour to release excellent manuscripts, as a preferred content article always gains a potential impact on the readers, so we would like to publish your renowned articles and we are positive that your contributions will definite help in emerging new concepts to the readers and emerging researchers.

The congress will highlight the theme “Progress and Novel Strategies in Vaccines and Immunology Research” to gather the researches, scientists, academicians and industrialists from around the world and also to set a common platform for discussion and exploring recent advances in Vaccines & Immunology research.

Vaccination is one of the best approaches to prevent illness. A vaccine assists the body's safe framework with recognizing and battle pathogens like infections or microorganisms, which at that point protects us from the illnesses they cause.