Journal of Antimicrobial Agents

Abstract

M. M El-ajaily*, M. M. Miloud, T. H. Al-noor, R. K. Mohapatra and N. S. Al-barki

A Schiff base (HL1), namely; [(S, Z)-2-((2-hydroxy-1-phenylethylidene) amino)-3-(4-hydroxyphenyl) propanoic acid] was synthesized by the condensation of 2-hydroxyacetophenone with an amino acid (L-Tyrosine) for one hour. Whereas, the other Schiff base (HL2), namely; (E)-4-((2-(2, 4-dinitrophenyl) hydrazono) methyl)-N, N-dimethylaniline] was synthesized by refluxing 4- dimethylaminobenzaldehyde and 2, 4-dinitrophenylhydrazine for one hour. The first Schiff base (HL1) used ad primary ligand and the second one is used as secondary ligand to form five mixed ligand complexes with Co(II), Ni(II), Cu(II), Zn(II) and Fe(III) ions. The synthesized mixed ligand complexes were subjected to several physiochemical techniques, in terms; CHN elemental analyses, molar conductivity, magnetic moments and spectroscopic tools (FT-IR, 1HNMR, electronic, E.P.R and mass spectra). The analytical and spectroscopic data showed the presence of an octahedral geometry for all the mixed ligand complexes. The free Schiff bases, metal salts and mixed ligand complexes were tested for their antifungal activities on some pathogenic fungi species [A. niger, A. flavus, Alternaria alternata, Rhizopus stolonifer].