Anghel Adrian Udrea
We all know that healthcare today is faced with ever greater challenges, while advances in research and innovations may open new possibilities for better health and improved care for cancer patients. 17th International Conference on Oncology Nursing and Cancer Care happened during March 04-05, 2020 at Edinburgh, Scotland is an international arena for frank and challenging dialogue, exploring possibilities and dilemmas associated with advancement in oncology and cancer. Cancer Nursing 2020 brought together cancer care professionals, thought leaders, doctors, researchers, entrepreneurs, nurses, professors, directors, oncologists at Edinburgh. Over two days, participants were encouraged to share experience, insights and strategies for moving the delivery of exceptional cancer care and permitting the professional well-being of the entire care team. The format of the meeting involved a mixture of exhibitions, keynote talks, presentations on topical issues, and extensive panel discussions, as well as the introduction of interactive working groups, and plenty of scheduled time for official and informal networking.
Anghel Adrian Udrea
QOPI® is a practice-based system of quality self-assessment operated by ASCO (American Society of Clinical Oncology) with the goals of improving cancer care and prevention. It promotes excellence in cancer care by helping practices to create a culture of self-examination and improvement. Medisprof cancer centre was seeking from the beginning ASCO standards as a proof of interest in quality of the services offered to the patients.
With a growing estimated 18.1 million new cancer cases and 9.6 million cancer deaths in 2018, cancer remains an uncontrolled worldwide plague. In both sexes combined, lung cancer is the most commonly diagnosed cancer and the leading cause of death worldwide, closely followed by female breast cancer, prostate cancer and colorectal cancer for incidence, and colorectal cancer, stomach cancer and liver cancer for cancer mortality. Among male’s lung cancer is both the most frequent cancer and the leading cause of cancer death; while among females’ breast cancer is both the most frequently diagnosed cancer and the leading cause of cancer deaths. Classically tobacco smoking, alcoholism and overweight/ obesity are cancer risk factors thought to be mainly involved in cancer occurrence and so be fought with preventive public health measures that hopefully would eradicate the disease.
This study was conducted to determine the effects of sound vibration on individuals with depression. The study also examined changes to the blood cells as observed through live blood analysis when the intervention of vibratory frequencies ranged from 64Hz to 600Hz. Variables consisted of a time frame of one hour of control group (n=17) listening to music from the position of a chair in a contained room, and experimental group (n=27) positioned on a sound vibrational treatment table. The random study was conducted on 7 males and 37 females with a minimal six-month diagnosis of depression. Measurement was accomplished through evaluation of live blood analysis level of aggregation and Profile of Mood States questionnaire for depression. A drop of blood from a finger puncture was obtained and examined through Darkfield microscopy for specific quality and level of visible clumping. Marilyn Parkin International College of Medical Intuition Inc, Canada Bio-Physical tendencies with applied methods of mind/body/soul techniques sound frequencies and including the art of intuition Post blood analysis determined less clumping and healthier activity of the cells after intervention in the experimental group. The live blood analysis of the control group remained unchanged. Profile of Mood States for Depression indicated there was no significant difference between the experimental and control groups. Results indicated an increase in mood state from the use of music and blood aggregation was reduced only with the sound vibrational treatment table.
At low middle-income countries like Egypt with prevalence of (HCV) which represent from 5 to 7% of total population. Hepatocellular carcinoma is one of major complications of HCV infection At Africa for example Egypt is accounting for approximately half of the data related to HCC. Over the last two decades, a substantial increase (from 4.0% to 7.2%) in the proportion of chronic liver disease Egyptian patients with HCC was observed. This percentage raise some questions like • How government afford innovative products for high number of patients? • Are these innovative products worthy for reimbursement? • What is the impact on budget? The main objective behind conducting this study was to conduct an economic evaluation of Sorafenib for the treatment of hepatocellular carcinoma in the Egyptian patients, compared to standard of care perspective of the National Fund over a time horizon of 4 years. To maximize health gain for the patients while ensuring the most efficient use of the finite resources available to the Egyptian Ministry of Health. Methods: A cost-effectiveness analysis from the payer perspective using Markov chain simulation model which is hypothetical cohort model to conforms to real practice of management of advanced HCC in Egypt.
piR-651 is a member of small non-coding RNAs which is called PIWI Interacting RNAs. piRNAs can regulate the function of transposons by both epigenetic and posttranscriptional silencing. Several studies indicated that piR-651 might be useful for diagnostic of cancer cases according to its oncogenic characteristics. In this study, we aimed to determine the effect of piR-651 on the molecular characteristics of MCF-7 breast cancer cells. Anti-piR-651 sequence was transfected to MCF-7 cells and then the effect of piR-651 on proliferation, adhesion and motility characteristics of cells were detected by using XTT kit procedure at 24th, 48th and 72nd hours. After determining the cellular behaviour changes, to determine the cellular changes of proliferation Ki-67; adhesion MMP-2 and MMP-9 gene expressions were determined by using RT-PCR. According to obtained data, inhibition of piR-651 caused to a decrease on proliferation and adhesion of MCF-7 cells (p<0.001). Ki-67 and MMP- 9 gene expressions are also supported the cellular behaviour assays of piR-651 inhibited MCF-7 cells (p<0.001). Moreover, motility assay showed that the migration rate of piR-651 inhibited MCF-7 cells were more Notes: slowly compared to untreated and non-target treated cells. In benign breast cancer cells line, piR-651 inhibition can change both cellular characteristics and gene expressions which were related to these characteristics. Especially, adhesion and proliferation are the important cellular marks of MCF-7 cells. piR-651 inhibition cause to decrease both proliferation and adhesion of cells, these results have shed on light whether we can mitigate the effects of cancer cells on the organism with piRNA inhibition. Our results indicated that changing the expression patterns of piRNAs might cause to change the fate of benign breast cells.
Surekha Stephen Dongerdive
Colorectal cancer (CRC) is a formidable health problem worldwide. It is the third most common cancer in men (663000 cases, 10.0% of all cancer cases) and the second most common in women (571000 cases, 9.4% of all cancer cases). Almost 60% of cases are encountered in developed countries. The number of CRC-related deaths is estimated to be approximately 608000 worldwide, accounting for 8% of all cancer deaths and making CRC the fourth most common cause of death due to cancer. In India, the annual incidence rates (AARs) for rectal cancer in men are 4.1 per 100000, respectively. The AAR for colon cancer in women is 3.9 per 100000. Colon cancer ranks 8th and rectal cancer ranks 9th among men. For women, rectal cancer does not figure in the top 10 cancers, whereas colon cancer ranks 9th. While the incidence rates of CRC is much lower in India, the survival rates for CRC are disproportionately lower. A stoma operation causes profound changes in a patient’s life because of the resulting physical damage, disfigurement, loss of bodily function, impaired or lack of interest in sexual function/ activity. It can change the person’s social life and make them feel different because they do not display the characteristics and attributes that society deems normal, due to their changed body. It may even lead social isolation and may find it difficult to understand the implications of a stoma. The nurse, as a member of the multi-professional team, has an important role in the process of counselling to the person with a stoma, as she has competence and assistential tools, such as Systematized Nursing Care, for detecting all the difficulties in adaptation that these clients may face in their condition of having stomas, as well as outlining together actions aimed at minimizing and overcoming such difficulties.
Awa Abdul Carimo
The prevalence of hepatitis B virus (HBV) infection and human immunodeficiency virus (HIV) infection in Mozambique is one of the highest in the world, though in spite of this the prevalence of occult hepatitis B infection (OBI) is unknown. The clinical impact of OBI is unclear, but it’s been related the increase of the risk of HBV transmission through blood transfusion, organ and bone marrow transplantation, HBV reactivation after immunosuppression and risk of progression to chronic liver disease and hepatocellular carcinoma. The aim of this study was to investigate the prevalence of OBI among antiretroviral (ART) naïve HIV-positive patients in Mozambique.
Ivana Haluskova Balter
Gastrointestinal tract is crucial for many physiological processes it plays an important role in inflammatory and immune reactions. Several internal and external factors can influence this population, and shifts in their composition, have been demonstrated to contribute and affect different diseases. During dysbiosis several bacteria related to inflammation, one of the most necessary factors in carcinogenesis; it has been shown that some bacterial strains through deregulation of different signals/pathways may affect tumor development through the production of many factors. Gut microbiota might be considered as a holistic hub point for cancer development: direct and indirect involvements have been studying in several neoplasms such as colon rectal cancer, hepatocellular carcinoma and breast cancer. Immune host response and resistance microbiome is composed from 100.000 milliards of bacteria. It forms protective barrier against pathogens (permeability) and interactive layer with inner host immune system and neuroendocrine System. It does play important role in development (training of host immune response), human health prevention.
Advances in molecular oncology and cancer genetics in the last 15 years have defined many of the key driving oncogenes in human cancer. Despite these successes it is now apparent that tumor cells adapt and develop acquired resistance to these targeted inhibitors so that disease progresses within a 5-7 months. At Gustave Roussy, we have opened a prospective clinical trial, MATCH-R (NCT02517892): is a prospective single-institution trial aiming to identify mechanisms of resistance to targeted agents and immunotherapy in patients with advanced cancer (NCT02517892). Patients was enrolled to MATCH-R study before initiated a therapy and then they achieved an initial partial or complete response or stability of disease for at least 6 months are included upon disease progression. Extensive molecular profiling with panel next-generation sequencing, whole exome sequencing (WES) and RNA sequencing (RNAseq) is performed on tumor samples. In the same time, we develop preclinical models (Patient derived xenograft, organoids, and Notes: cell lines) at the stage of acquired resistance. These models will be used to improve our knowledge on the mechanisms underlying resistance to treatment and to develop new therapeutic strategy set up for the patient. As November 2019, 200 tumor biopsies were taken from patients to develop 70 PDX models, 20 organoids and 30 cell lines to develop preclinical research at Gustave Roussy. We carry our efforts on androgen therapy for prostate cancer, ALK/EGFR inhibitor for lung cancer and FGFR inhibitors for bladder and cholangiocarcinoma.
PIWI interacting RNAs (piRNAs) are the novel members of small non-coding RNAs which cannot produce any protein but are effective on transcription and posttranscriptional mechanisms of cells. Coumarin derivates can be used as a drug in various types of diseases. In this study we used an isoform of coumarin which is called 4-OH-Coumarin. In scientific literature, there is not enough researches about coumarin treatment in hepatocellular carcinoma. In this study, we aimed to determine the effect of 4-OH-Coumarin on piR-Hep-1 and piR-651 expressions of HePG2 cells. According to our previous study, the optimal concentration and time of 4-OHCoumarin was treated to HePG2 hepatocellular carcinoma cells. After treatment, total RNA was isolated and the expression changes of piR-Hep-1 and piR-651 was determined on these cells by using Real Time Polymerase Chain Reactions (RTPCR). According to our obtained data, statistically significant upregulation of piR-651 expressions was observed in 4-OH-Coumarin treated HePG2 cells compared to control (P<0.001). On the other hand, the expression of piR-Hep-1 did not affect from 4-OHCoumarin treatment statistically Notes: significant (P>0.05). In scientific literature, the expression patterns of piR-Hep-1 is not clear yet. In some types of cancer types, it was upregulated, but it was downregulated in some types of cancer types. Our results indicated that about 4-OHCoumarin is useless to determine the piR-Hep-1 expression pattern. This result is significant to clarify the relationship between piR-HeP-1 and 4-OH-Coumarin treatment. Generally, piR-651 is downregulated in circulating tumor cells. Our results indicated that 4-OH-Coumarin treatment on HePG2 cells might be effective to regulate the effect of piR651. All these data indicate that some of piRNAs might have special expression patterns in hepatocellular carcinoma and these expression patterns can be regulated by treated natural compounds which are used to inhibit the effects of cancer cells.
Razia Bano Shaukat
Gilgit –Baltistan is a location where there is only 1 percent arable land is available. The population is growing fast. People are shifting their main crops to cash crops. The general observation is that food is the main reason for breast and stomach cancer. There is a town called danyor.60 years ago this area was very famous for cancer. Now still people are suffering from the disease. The poster will show the overall situation and types of cancer in this area. I am teaching entrepreneurship and my work is in food security. Female have breast cancer, skin cancer and male have stomach cancer and brain tumor problems. We do not have cancer hospital; people need to travel 18 hours to reach city hospital of cancer. The area is covered with highest mountains and glaciers. World’s 2nd highest peak K-2, Masherbrum and Gasherbrum is in this region.