Konstantinos A Zorbas, Sunil Karhadkar, Kelvin Kwan N Lau and Antonio Di Carlo
Temple University Hospital, USA
Posters & Accepted Abstracts: J Transplant Technol Res
Introduction: The first successful combined heart-kidney transplantation (HKTx) underwent in 1986 and since then the prevalence of this procedure has increased dramatically. Survival outcomes in HKTx seem to be similar to those for kidney transplantations alone (KTx). Aim: Aim of this study is to examine whether combined HKTx have the same survival outcomes or not, compared with those of kidney transplantation in the first two years. Methods: Temple University Hospital Database was queried from 1990-2015 for patients with heart and renal failure, who underwent HKTx and we found 20 cases. Data were extracted with reference to age (at transplantation), gender, race, weight (BMI), diabetes mellitus status, coronary artery disease status, hypertension status and date of transplantation. A control group of solitary KTx recipients was selected from the same database that underwent transplantation during the same time period. The control group was matched with HKTx for age at transplantation (├?┬▒2 years), gender and race. Kaplan-Meier method was used to identify the first two years survival outcomes in these two cohorts. Results: Out of 20 patients who underwent HKTx, seven died during the first year after transplantation and from the cohort of solitary KTx only one patient died, particularly during the second year. Mortality in the HKTx group was higher in comparison with the mortality in solitary KTx cohort, particularly with statistically significant difference (.012). Conclusions: Combined heart-kidney transplantations have higher incidence of mortality during the first year after transplantation. Additional studies are needed to determine the long-term mortality and which patients are suitable for HKTx.
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