Role of exercise-induced free radical production on brain function

2^nd International Conference on Sports Medicine and Fitness

April 18-20, 2016 Dubai, UAE

Zsolt Radak

University of Physical Education, Hungary

Posters & Accepted Abstracts: J Sports Med Doping Stud

Abstract :

Regular exercise has systemic beneficial effects including the promotion of brain function. The adaptive response to regular exercise includes the up-regulation of the enzymatic antioxidant system, and modulation of oxidative damage. Reactive oxygen species (ROS) are important regulators of cell signaling and exercise through activity dependent modulation of metabolism and/or direct activation of ROS generating enzymes, thus, modulating the cellular redox state in the brain. ROS are also involved in the self-renewal and differentiation of neuronal stem cells and, as a result, exercise-mediated neurogenesis could be associated with ROS production. Exercise has a powerful effect on the immune system, and readily alters the production of cytokines. Certain cytokines, especially IL-6, IL-1, TNF-�±, IL-18 and IFN�³ are actively involved in the modulation of synaptic plasticity and neurogenesis. Cytokines can also contribute to ROS production. ROS- mediated alteration of lipids, protein and DNA could directly affect brain function while exercise modulates the accumulation of oxidative damage. Oxidative alteration of macromolecules to a moderate degree can activate signaling processes. Hence, it could be a part of the adaptive response to exercise training.

Biography :

Email: radak@tf.hu