Commentary - (2025) Volume 11, Issue 1
Received: 01-Feb-2025, Manuscript No. jctt-25-168469;
Editor assigned: 03-Feb-2025, Pre QC No. P-168469;
Reviewed: 15-Feb-2025, QC No. Q-168469;
Revised: 21-Feb-2025, Manuscript No. R-168469;
Published:
28-Feb-2025
, DOI: 10.37421/2471-9323.2025.11.301
Citation: Wright, Makin. "Regenerative Applications of Platelet-Rich Plasma in Cosmetic Gynaecology: A Systematic Review." J Cosmo Tricho 11 (2025): 301.
Copyright: © 2025 Wright M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
PRP is derived from autologous blood through centrifugation, yielding a concentrate of platelets in plasma that contains higher-than-baseline levels of growth factors and cytokines. These biologically active molecules play a critical role in wound healing, tissue repair and cellular proliferation. The fundamental mechanism of PRP in regenerative medicine lies in its ability to recruit stem cells, stimulate neovascularization and enhance extracellular matrix remodeling. In gynaecology, PRP is typically injected intradermally or submucosally into the vaginal wall, clitoral body, or labia depending on the indication. Its non-allergenic nature and minimal risk of adverse reactions make it an attractive option for women seeking natural, non-surgical interventions for genital rejuvenation.
One of the primary indications for PRP in cosmetic gynaecology is the treatment of vaginal atrophy, particularly in postmenopausal women. Estrogen deficiency leads to thinning of the vaginal epithelium, reduced elasticity, decreased lubrication and increased susceptibility to infections and discomfort. PRP injections into the vaginal mucosa have shown to improve epithelial thickness, enhance vascularity and restore mucosal elasticity. Studies have reported significant improvements in symptoms such as dryness, dyspareunia (painful intercourse) and vaginal laxity following PRP treatment. When used as a monotherapy or in combination with fractional COâ?? laser therapy, PRP has yielded positive outcomes in terms of both subjective satisfaction and histological evidence of tissue regeneration. Female sexual dysfunction encompasses a range of issues including decreased libido, impaired arousal, anorgasmia and sexual pain disorders. PRP, particularly when administered via the O-Shot (Orgasm Shot), has gained popularity as a novel therapeutic approach to address FSD. The procedure involves injecting PRP into the clitoral body and anterior vaginal wall near the G-spot to enhance sensitivity and sexual responsiveness.
Several observational studies and pilot trials have shown improved scores on the Female Sexual Function Index (FSFI) after PRP therapy. Patients have reported heightened arousal, increased vaginal lubrication and enhanced orgasmic intensity. While placebo-controlled trials are limited, the existing literature supports the potential role of PRP in restoring sexual wellness by revitalizing neurovascular structures and promoting neurosensory regeneration. Stress urinary incontinence-a condition characterized by involuntary urine leakage during physical exertion-affects a substantial proportion of women, particularly after childbirth or during menopause. PRP therapy has been explored as a minimally invasive treatment for mild to moderate SUI. By injecting PRP into the periurethral and vaginal tissues, the growth factors stimulate collagen synthesis and improve the integrity of the urethral sphincter. Early studies indicate a reduction in incontinence episodes, improved pelvic support and patient-reported satisfaction post-treatment. Although PRP is not yet a standard of care, it holds promise as an adjunct or alternative to surgical procedures and pelvic floor exercises. Aesthetic concerns related to the labia majora and minora-such as volume loss, sagging, or wrinkling-can negatively impact a woman's body image and confidence. PRP injections are being used for labial augmentation to restore volume and firmness by stimulating adipocyte and fibroblast activity. Unlike dermal fillers or fat grafting, PRP offers a natural approach that rejuvenates the tissue without introducing foreign materials. When combined with microneedling or hyaluronic acid fillers, PRP enhances collagen induction and prolongs the results, creating a youthful and hydrated appearance of the external genitalia [4,5].
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