Systemic scleroderma (SSc) is a complex autoimmune rheumatic disease in which inflammation, fibrosis and vasculopathy share several pathogens that cause skin and internal organ damage. Recent discoveries concerning the participation and interaction of the innate and acquired immune system have led to a better understanding of the pathogenesis of the disease and to the identification of new therapeutic targets, many of which have been tested in preclinical and clinical trials with variable results. In this manuscript, we review the state of the art in the pathogenesis of this disease and discuss the main therapeutic targets related to each pathogenic mechanism that have been discovered so far.
2021 Conference Announcement: Journal of Dermatology and Dermatologic Diseases
2021 Conference Announcement: Journal of Dermatology and Dermatologic Diseases
Review Article: Journal of Dermatology and Dermatologic Diseases
Review Article: Journal of Dermatology and Dermatologic Diseases
Research Article: Journal of Dermatology and Dermatologic Diseases
Research Article: Journal of Dermatology and Dermatologic Diseases
Short Communication: Journal of Dermatology and Dermatologic Diseases
Short Communication: Journal of Dermatology and Dermatologic Diseases
Research Article: Journal of Dermatology and Dermatologic Diseases
Research Article: Journal of Dermatology and Dermatologic Diseases
Posters & Accepted Abstracts: Cancer Science & Therapy
Posters & Accepted Abstracts: Cancer Science & Therapy
Accepted Abstracts: Journal of Forensic Research
Accepted Abstracts: Journal of Forensic Research
Posters: Alternative & Integrative Medicine
Posters: Alternative & Integrative Medicine
Scientific Tracks Abstracts: Journal of Health & Medical Informatics
Scientific Tracks Abstracts: Journal of Health & Medical Informatics
Posters & Accepted Abstracts: Journal of Nephrology & Therapeutics
Posters & Accepted Abstracts: Journal of Nephrology & Therapeutics
Journal of Dermatology and Dermatologic Diseases received 4 citations as per Google Scholar report