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International Journal of Public Health and Safety

International Journal of Public Health and Safety

ISSN: 2736-6189

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Circulating Angiotensin Open Access Journals

The renin-angiotensin system is a signalling pathway that acts as a homeostatic regulator of vascular function. Its systemic behavior include the governance of blood pressure, natriuresis, and blood volume control. However, the RAS also plays an far-reaching local role, regulating regional blood flow and controlling trophic responses to a range of stimuli. Many of these components have opposing functions to accommodate a rapid but coordinated response to specific triggers. Angiotensin I (Ang I) is metabolised by the dipeptide carboxypeptidase, angiotensin-converting enzyme to form angiotensin II (Ang II) and Ang II is metabolised by the carboxypeptidase, ACE2, producing the vasodilator, angiotensin . Historically, ACE and Ang II have been the key focus for clinical interventions targeting the RAS and its pathogenic actions. However, recent studies have also demonstrated the concern of ACE2 in maintaining the balance of the RAS. ACE2 may be more important than ACE in regulating local levels of Ang II and Ang and therein the balance of RAS activation. By contrast, Ace KO mice have modestly reduced circling Ang II, while tissue levels are not significantly modified, possibly as substantial amounts of Ang II are generated by non-ACE pathways, while degradation boulevard for Ang II are more limited.

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Citations: 370

International Journal of Public Health and Safety received 370 citations as per Google Scholar report

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