Journal of Inflammatory Bowel Diseases & Disorders

ISSN: 2476-1958

Open Access

Articles in press and Articles in process

    Editorial Note Pages: 1 - 1

    TE Events and Risk Factors in IBD

    Francisco Ab�?­lio da Silva Portela

    The increasing evidence regarding TE events and risk factors in IBD patients demands a better disease control in order to reduce these feared vascular complications.Additionally, a higher or should be evoked to increase the rate of venous TE prophylaxis in IBD inpatients.

      Editorial Pages: 1 - 1

      Aleah Ahadi*

      Inflammation is your body's attempt to heal itself by fighting against things that hurt it, such as infections, injuries, and toxins. When your cells are damaged, your body releases substances that cause your immune system to respond. This response includes the release of antibodies and proteins, as well as increased blood flow to the damaged area. The whole process usually lasts for a few hours or days in the case of acute inflammation. some time, this can prompt DNA harm, tissue passing, and inner scarring. All of these are linked to the development of several diseases, including cancer, heart disease, rheumatoid arthritis, type 2 diabetes, obesity, asthma.

      Editorial Pages: 1 - 1

      Amir Karban*

      Lymphocytic colitis is a medical issue that causes aggravation of your internal organ. It causes scenes of watery the runs and midsection torment. Your internal organ is important for your stomach related (gastrointestinal or GI) parcel. It incorporates both the colon and rectum. It goes from your mouth right to your rectal opening. The digestive organ gets the separated results of food from the small digestive tract. One of its primary positions is to reabsorb water and electrolytes, like salt. The colon prompts the rectum, which stores your excrement before your body removes them.

      Editorial Pages: 1 - 1

      Prathap Nadar*

      Microscopic Colitis (MC) is a provocative inside problem portrayed by watery nonbloody looseness of the bowels. It is all the more entirely expected in females and patients more than 50 years old and its pathophysiology isn't completely perceived. Clinical biomarkers, for example, fecal calprotectin are typically ordinary and side effect cross-over with useful problems may prompt dithering in continuing with additional examinations, subsequently postponing the finding. Clinical scores can assist with anticipating those in danger of MC, just as screen illness action. Histology is fundamental in diagnosing MC and its two subtypes, lymphocytic and collagenous colitis. In any case, ongoing mechanical advances have empowered us to depict a few inconspicuous naturally visible changes that can make the sharp looked at endoscopist aware of the presence of the condition. Endorsed drugs can represent about 10% of MC cases. Other danger factors incorporate simultaneous immune system problems and smoking. Along these lines, the remedy of proper prescriptions along with the appraisal for any auxiliary reason, are fundamental in the administration calculation of this infection.

      Full Length Research Paper Pages: 1 - 4

      Irritable Bowel Syndrome or Just Inefficient Bowel-Emptying Syndrome - Explaining the Overlap of Gastro-Oesophageal Reflux Disease with Functional Gastrointestinal Disorders through the Effects of Colonic Distension

      Scott B. Simpson

      Colonic distension is not only the main trigger of functional colonic pain, but also activates multiple different reflexes affecting both upper and lower gastrointestinal (GI) motility. Irritable bowel syndrome (IBS) patients have been documented with increased colonic faecal loading on abdominal x-ray. Medications, reduced mobility and probably hereditary factors which promote colonic stasis along with poorly digested fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAPs) which increase colonic distension are known to trigger colonic symptoms. Colonic decompression has been shown to improve both functional colonic and upper gut symptoms as well as reducing typical gastro-oesophageal reflux disease (GORD) and laryngopharyngeal reflux (LPR) symptoms. The right colon appears to play an important role in regulating whole gut motility. GI smooth muscle functions according to the Frank-Starling principle where progressive distension initially promotes and later impairs motility and must be taken into account when selecting appropriate medical therapy. Colonic stasis is associated with the more benign form of acute ischaemic colitis. In mouse studies, colonic distension from a high FODMAP diet may well induce low-grade mucosal ischaemia, barrier dysfunction and ongoing low-grade inflammation causing IBS symptoms. Gut physiology suggests that occult constipation or proximal colonic faecal loading acts as a functional obstruction, which must be addressed by medical therapy to treat functional upper GI symptoms and refractory reflux optimally. Improvement in functional colonic symptoms with simple laxative therapy and other agents which promote colonic motility such as prucalopride correlates strongly with improvement in dyspeptic, refractory GORD and LPR symptoms.

      Commentry Pages: 1 - 1

      Coffee consumption prevents liver cancer development

      Abhishek Bhurwal

      Coffee consumption has its benefits on human health. In the specific area of hepatology, previous studies have suggested that coffee
      decreases liver enzymes and inhibits progression of liver fibrosis. Additionally, in a recent systematic review and meta-analysis, coffee
      consumption was shown to have an inverse association with the development of liver cancer. That well-designed study suggested that coffee
      drinking would be beneficial in terms of preventing liver cancer. Coffee drinkers at risk of developing hepatocellular cancer should consider the
      potential benefits of drinking coffee.

      Editorial Pages: 1 - 2

      Dani Fasil*

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        Editorial Pages: 1 - 1

        Pinpointing of Lethal Dependencies

        Puja Sakhuja

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          Review Article Pages: 1 - 6

          Clinico-Pathological Predictors of Colonic Eosinophilia in Childhood: A Single-Center Study

          Mohammad Naghi*, Khaled Zalata, Magdy Ibrahim, Khadega Ali, Khaleel Wafi and Ahmed Abdullah

          DOI: 10.37421/2476-1958.2022.7.171

          Objectives: Childhood colonic eosinophilia is a perplexing outcome with a broad differential. The practitioner has little guidance on how to approach these patients. We examined individuals with colonic eosinophilia and studied the clinic pathological parameters correlated with their diagnoses. We aimed to see if we could find predictors of colonic eosinophilia without colonoscopy and if these predictors could be used for monitoring. This was achieved so that a colonoscopy would not have to be used unless there was doubt about the diagnosis.

          Methods: In order to compare children with colonic eosinophilia (N=56) in their histopathology to controls without the condition (N=120), we conducted a 10 years retrospective chart review.

          Results: Individuals with colonic eosinophilia had significant clinical and laboratory characteristics contrasted to controls (p<0.001). Age, platelet count, and fecal calprotectin were the three factors that might be considered predictors in diagnosing Colonic Eosinophilia.

          Conclusions: Age, platelet count, and calprotectin were good predictors for colonic eosinophilia cases. Such predictors could be of value in monitoring patients.

          Review Article Pages: 1 - 2

          Inflammatory Bowel Disease: Immune Function, Tissue Fibrosis and Current Therapies

          Rajesh Kumar*

          DOI: 10.37421/2476-1958.2022.7.170

          Fiery inside illness (IBD) alludes to ongoing and backsliding provocative problems of the gastrointestinal lot. Among the two fundamental elements of IBD, Crohn's Illness (CD) is a transmural irritation that might influence any piece of the gastrointestinal parcel, while Ulcerative Colitis (UC) is an irritation of the colonic mucosa and submucosa. The two types of IBD can unfavorably affect all parts of patients' life, remembering a significant crumbling for their personal satisfaction. While the frequency and pervasiveness of IBD stay most elevated in Western nations, they have as of late expanded in recently industrialized locales. In the 21st 100 years, fiery entrail illness has turned into a worldwide sickness, with north of 6,000,000 cases overall.

          Review Article Pages: 1 - 3

          Pathophysiology and Treatment of Inflammatory Bowel Disease

          Jay Pravda*

          DOI: 10.37421/2476-1958.2022.7.172

          Ongoing investigations have shown dysbiosis is related with fiery entrail illness (IBD). Notwithstanding, attempting to reestablish microbial variety through waste microbiota transplantation (FMT) or probiotic mediation neglects to accomplish clinical advantage in IBD patients. We played out a probiotic mediation on a recreated IBD murine model to explain their relationship. IBD was mimicked by the convention of Azoxymethane and Dextran Sodium Sulfate (AOM/DSS) to set up a colitis and colitis related neoplasm model on BALB/c mice. A solitary probiotic mediation utilizing Clostridium Butyricum Miyairi (CBM) on AOM/DSS mice to explain the job of probiotic in colitis, colitis related neoplasm, stomach microbiota, and safe cytokines was performed. We found dysbiosis happened in AOM/DSS mice. The CBM mediation on AOM/DSS mice neglected to further develop colitis and colitis related neoplasms however changed microbial arrangement and suddenly expanded articulation of proinflammatory IL-17A in rectal tissue. We estimated that the probiotic mediation caused dysbiosis. To explain the outcome, we performed converse FMT utilizing dung from AOM/DSS mice to typical beneficiaries to approve the pathogenic impact of dysbiosis from AOM/DSS mice and found mice on reverse FMT created colitis and colon neoplasms. We assumed the probiotic intercession somewhat caused dysbiosis as converse FMT. The job of probiotics in IBD requires further clarification.

            Research Article Pages: 1 - 5

            Can high calprotectin level predict mortality in patients with COVID-19?

            Maryam Sadat Mousavi*

            DOI: 10.37421/2476-1958.2023.08.175

            Background: Some biomarkers such as C-reactive protein (CRP) and Fecal Calprotectin (FC) have been reported to be related to the prognosis of the coronavirus disease 2019 (COVID-19).

            Methods: This case control study included 76 IBD patients in clinical remission and COVID-19 patients from December 2021 to March 2022. A checklist including demographic and clinical parameters was filled out for each participant. Two stool samples in 2 stages (during one month) and one blood sample were collected to test for FC and CRP, respectively. Data were analyzed using Wilcoxon, Mann Whitney, Spearman, T-test, ANOVA and K2 tests and P<0.05 was considered significant.

            Results: 33 COVID-19 patients and 43 remission IBD cases with a mean age of 51.53 ± 15.155 years take part in the study. In COVID-19 group, mean FC ± SE in the first samples were 184.46 ± 59.01 (µg/g) and 144.58 ± 38.68 (µg/g) in the second samples one month later. In IBD patients in clinical remission mean FC in the first and in the second samples were 170.25 ± 42.23 (µg/g) and 204, 35 ± 68.33 (µg/g). The reduction in FC was significant among patients with COVID-19 (severe and moderate) after one month. 8 and 11 cases with COVID-19 and IBD had FC1 above or equal 200 (µg/g), respectively. Among 8 COVID-19 patients with high level FC1, 5 cases died. Mean CRP was 44.30 ± 3.47 in COVID-19 and 4.93 ± 1.00 in IBD patients (P<0.05). In cases, a correlation was seen between FC1 and CRP (rs=0.353, P=0.04).

            Conclusion: Our findings showed gastrointestinal inflammation in COVID-19 patients even a month after recovery. More mortality was observed in patients with FC above 200. Higher level FC is presented in older COVID-19 patients that show the patients need special attention. Further studies are needed to understand the role of Calprotectin in predicting COVID-19 mortality.

            Mini Review Pages: 1 - 3

            Alternative and Complementary Medicine in Treatment of Irritable Bowel Syndrome

            Robert Ibsen*

            DOI: 10.37421/2476-1958.2023.08.182

            The benefits of current pharmacological therapy are minimal. Tricyclic antidepressants have strong clinical support, although antispasmodics and selective serotonin reuptake inhibitor antidepressants have weaker clinical evidence. Due to potential hazards, serotonin subtype targeting drugs are not frequently used. Both alosetron and tegaserod, which are not approved for usage in Canada, are linked to cardiovascular events and ischemic colitis, respectively. It is not surprising that nearly 50% of IBS patients seek out Complementary and Alternative Medicine (CAM) therapies given their low levels of satisfaction with therapy they receive. The national center for complementary and alternative medicine defines Complementary and Alternative Medicine (CAM) as medical procedures that are not currently regarded as a part of mainstream medicine. It must be noted right away that this definition is rather arbitrary and that what is and is not considered CAM will depend on a variety of circumstances, including cultural, racial, social, religious, educational, economic, and other considerations, as well as the attitude of the local medical community. As an illustration, the use of aromatherapy as a support for pharmaceutical analgesia in the post-operative patient illustrates how complementary medicines or medical practices are, by definition, administered or used in addition to traditional medicines. Alternative medications or medical procedures are utilised instead of standard medicines or procedures; an illustration of this would be the decision to treat cancer with a particular diet rather than surgery, radiation therapy, or chemotherapy. An approach to patient treatment known as integrative medicine mixes "mainstream" and Complementary and Alternative Medicine (CAM) methods and/or therapies. This approach has been shown to be safe and effective in a number of different contexts.

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