Molecular Biology: Open Access

ISSN: 2168-9547

Open Access

Devapriya Apukuttan

Department of Periodontics, SRM Dental College, SRM University, India

  • Mini Review   
    p53 and c-Myc in Reprogramming Energy Metabolism in Metastasis
    Author(s): M. Jasmine Crena*, Lalli Dharmarajan, PSG Prakash, Sangeetha Subramaniam and Devapriya Apukuttan

    Cancer, a highly morbid and mortal disease, which shows properties of metastasis thereby tumours formation at a distant site has been in the last decade been probed and overwhelmingly researched and has been shown to have two significant emerging hallmarks in the pathogenesis of metastasis which are (a) Reprogramming Energy Metabolism (REM) and (b) Evading Immune Destruction (EID). REM has the ability to reprogram and modify the cellular status whilst EID has the ability to evade the natural killer (NK) cells and the macrophages. Cancer cells get benefited by these features in terms of acquisition of nutrition, uptake of glucose, metabolic interactions with the micro environment, thereby resulting in increased nitrogen demand. In this paper, we have discussed the benefits of these emerging hallmarks for cancer cells to sustain and proliferate inside the body an.. Read More»
    DOI: 10.37421/2168-9547.2022.11.351

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