Transplantation Technologies & Research

Very Coulic

Publications

• Research Article
  An Alternative Technique for Heart Lesion in the Rat: A Step to Fetal Heart Implantation for Cardiac Tissue Repair Running Title: A New Technique of Heart Lesion in Rat
  Author(s): Very Coulic, Sébastien Queron, Constantin Stefanidis, Paul Delree, Carine De Prez, Esmail Najar Saligheh and Pierre BergmannVery Coulic, Sébastien Queron, Constantin Stefanidis, Paul Delree, Carine De Prez, Esmail Najar Saligheh and Pierre Bergmann
  
  Existing experimental models of cardiac lesion do not allow precise reproducible dimensions of injury with complete safeness of surrounding tissues and cannot answer the tremendous question for heart cell therapy: are the implanted cells unable to influence the heart healing process or do the conditions in the injured heart prevent their complete development and integration?60 rats were used for elaborating an alternative technique of cardiac lesion.The anterior apical area of the heart was cauterized with a «Cautery high temperature fine tip» to create an injury of controllable, precise and reproducible dimensions (8×8 mm² surface, 1 mm depth).To evaluate functional and morphological characteristics of the lesion, electrocardiography, pulse oximetry, echocardiography and optic microscopy were performed at different times (from day 0 to 230) after.. Read More»
  DOI: 10.4172/2161-0991.1000149

  Abstract PDF