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Journal of Immunobiology

ISSN: 2476-1966

Open Access

Thomas G Bird

Centre for Liver and Digestive Disorders,
Royal Infirmary of Edinburgh, Edinburgh, EH16 4SA
United Kingdom

Publications
  • Short Communication
    The Evolution of the Use of Serum Alpha-fetoprotein in Clinical Liver Cancer Surveillance
    Author(s): Sarah-Louise Kelly and Thomas G BirdSarah-Louise Kelly and Thomas G Bird

    Liver cancer is the 6th most common cancer and 2nd leading cause of cancer-related mortality. In order to improve patient survival early tumor detection is required and this necessitates accurate screening of at risk individuals. In this article we concisely review the methodologies employed for Hepatocellular Carcinoma (HCC) surveillance and how their use has evolved over the last three decades. We focus attention to serum biomarkers, particularly alpha-fetoprotein. We propose that by using an increasingly sophisticated approach to assess dynamic rates of change in biomarkers tailored to individual patients that screening accuracy may be improved. Additional improvements may also be possible by the incorporation of patient clinical data into such personalised screening assessments. These possibilities may hold the promise of improving cancer detection and early curative therapy for t.. Read More»
    DOI: 10.4172/2476-1966.1000116

    Abstract PDF

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