Transplantation Technologies & Research

Thambi Dorai

Publications

• Research Article
  Induction of Hypometabolism as a Novel Strategy to Minimize Ischemia Reperfusion Injury in Renal Reconstruction Surgeries
  Author(s): Bobby Alexander, Meris James, Andrew Fishman, Michael Grasso and Thambi DoraiBobby Alexander, Meris James, Andrew Fishman, Michael Grasso and Thambi Dorai
  
  Purpose: Hibernation is an altered physiological state which is marked by a characteristic lowering of body temperature and extreme metabolic rate depression. During this period, an animal undergoing hibernation may have its heart rate and blood flow decrease to 1/30 and its oxygen consumption to 1/100 of its respective euthermic levels. Even though these physiological parameters mimic conditions of ischemia their organs particularly their brain, heart, liver and kidneys do not show any detrimental effects of severely reduced blood flow when the animal comes out of hibernation. We wished to explore the benefits of inducing such a hypometabolic state in a mouse ischemiareperfusion injury model. Methods: We investigated the pre-conditioning effect of administering 5’-Adenosyl Monophosphate (5’-AMP) to mice to create a state of hypome.. Read More»
  DOI: 10.4172/2161-0991.1000164

  Abstract PDF