Journal of Dermatology and Dermatologic Diseases

Ragip Ismail Engin

Publications

• Review Article
  A Rare Cause of Pigmentation Disorder; Tuberous Sclerosis Complex
  Author(s): Ragip Ismail Engin and Atilla CayirRagip Ismail Engin and Atilla Cayir
  
  Tuberous sclerosis complex is an autosomal dominant neurocutaneous disease principally characterized by the triad of mental retardation, adenoma sebaceum and epilepsy. It may affect all organs, but most commonly the skin, brain, heart, eyes and kidneys. The earliest finding, and the most common in the skin, consists of hypopigmented macules (ash leaf). In addition, numerous small hypopigmented macules (confetti-like macules) occur in the pretibial region. Shagreen patches, a form of collagenoma, may be seen in the lumbosacral region in half of patients. Skin findings also include angiofibromas, known as adenoma sebaceum, in the face and Koenen’s tumor. Other skin lesions include cafe-au-lait spots and molloscum fibrosum pendulum resembling acrochordon. We describe the skin findings in particular of tuberous sclerosis complex in the light of the current literature. .. Read More»
  DOI: 10.4172/2376-0427.1000211

  Abstract PDF