Molecular Biology: Open Access

Mingrui Zhang

Publications

• Review Article
  PTP1B, A Potential Target of Type 2 Diabetes Mellitus
  Author(s): Jia Sun, Chao Qu, Yajun Wang, Hui Huang, Mingrui Zhang, Hongyan Li, Yejun Zhang, Yang Wang and Wei ZouJia Sun, Chao Qu, Yajun Wang, Hui Huang, Mingrui Zhang, Hongyan Li, Yejun Zhang, Yang Wang and Wei Zou
  
  Diabetes is one of the common metabolic diseases, mainly divided into two types, type 1 diabetes mellitus and type 2 diabetes mellitus. Insulin resistance is the main performance of type 2 diabetes mellitus which are relative to some gene mutation, genetics, obesity and so on. Protein-tyrosine phosphatase 1B (PTP1B) plays an important role as a negative regulator in insulin signaling pathways that are implicated in metabolic diseases such as obesity and type 2 diabetes. Many evidences from clinical and basic researches show that the high expression of PTP1B induces insulin resistance. It appears that PTP1B is an effective target for the treatment of type 2 diabetes mellitus. In this review, we briefly introduce composition of PTP1B and the role of PTP1B in insulin signaling of type 2 diabetes mellitus. We also summarized recent research progress of PTP1B inhibitors used in therapy of .. Read More»
  DOI: 10.4172/2168-9547.1000174

  Abstract PDF