Molecular Biology: Open Access

ISSN: 2168-9547

Open Access

Marzooq Ammar AL


  • Thesis
    Discovery of Novel DNA Variants in Jordanians Population by Re-Genotyping Affymetrix DMET Arrays Data Using DNA Sequencing
    Author(s): Marzooq Ammar ALMarzooq Ammar AL

    The Affymetrix DMETTMM plus platform (Affymetrix, Santa Clara, CA, USA) is a GeneChip where 1936 SNPs can be genotyped in any given sample at once. The 1936 SNPs were distributed cross 225 genes in the genome. Thirtynine genes on the chip belong to phase I–II drug metabolism, disposition and drug transport gene family. These genes are functional in metabolizing the most widely prescribed anticancer drugs in the world including aromatase inhibitors, tamoxifen and thiopurines groups. In a high-throughput GeneChip array which is based on hybridization with allelespecific probes; genotyping errors are very common which limits the technologies applications; in addition missing calls for many SNPs on the chip immerge as a bigger and more serious problem in high- throughput genotyping methods. This study focuses on re-genotyping these No-call genotypes to maintain sample siz.. Read More»
    DOI: 10.4172/2168-9547.1000126

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