Journal of Dermatology and Dermatologic Diseases

Fabrizio Guarneri

Publications

• Research Article
  Etiopathogenesis of Melasma
  Author(s): Fabrizio GuarneriFabrizio Guarneri
  
  Known since ancient times, melasma is notoriously a frequent dyspigmentation disorder characterized by localized, chronic acquired cutaneous hypermelanosis. Despite high frequency, significant negative effects on quality of life and often unsatisfactory results of available treatment, not much research has been performed on the etiopathogenesis of this disease, which still remains largely obscure. An extensive review of the literature on etiology and pathogenesis of melasma is presented here, in which known causal/exacerbating factors (sun exposure, alterations of hormonal balance, use of cosmetics and photosensitizing drugs, procedures and inflammatory processes of the skin, stressful events) are linked with their effects on multiple metabolic pathways of melanocytes and other components of the socalled “melanin unit”. Available data outline an incompletely defined, but c.. Read More»
  DOI: 10.4172/2376-0427.1000S1003

  Abstract PDF