Journal of Dermatology and Dermatologic Diseases

ISSN: 2684-4281

Open Access

Bhanu Iyengar

Iyengar Farm,
Brijwasan Road, PO Kapashera, New Delhi-110037

  • Review Article
    Tumor Vascular Interaction in Melanomas and Neurogenesis: A Review
    Author(s): Bhanu IyengarBhanu Iyengar

    Background: Melanomas arise from multipotent neural crest derivative, the melanocytes. At the tumor-stroma interphase, melanoma cells show organized neural differentiation forming tumor-vascular complexes. The present study explores the sequence of neurogenesis from aurophilic radial glial like cells in relation to angiogenesis, utilizing the tumor-vascular-complex (TVC) as a 3D model. Methods: Serial frozen and paraffin sections stained with HE, reticulin-gold impregnation for aurophilia; dopa oxidase; immunopositivity for: neural differentiation (nestin, Glial Fibrillary Acidic Protein (GFAP), Neural Fibrillary Protein (NFP), synaptophysin); indoleamines: (serotonin and melatonin), catecholamines (dopamine (DA), Noradrenalin (NA), pigment; Dopa Oxidase (DO)); hormones: ((PRL), Prolactin; (HGH), Human Growth Hormone;) and mitosis. The pattern of neural differentiation in tumor-vascul.. Read More»
    DOI: 10.4172/2376-0427.1000112

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