Journal of Dermatology and Dermatologic Diseases

Sarcoidosis and Sjögren's syndrome (SS) coexistence has long been overlooked because sarcoidosis is considered an exclusion criterion for SS. We described a 55-year-old woman who had been diagnosed for 16 years with coexisting neurosarcoidosis and Sjögren's syndrome. She had erythema nodosum, progressive sensory and motor impairment of the extremities, dry mouth, and dry eyes when she arrived. A symmetrical pulmonary micronodule, interstitial changes, and enlarged mediastinal lymph nodes were seen on high-resolution computed tomography (HRCT) of the chest. Magnetic resonance imaging (MRI) of the spine revealed syringomyelia and thickening of the T3-9 spinal cord. She had positive ANA and anti-SSA antibodies, as well as impaired lacrimal, salivary gland, and renal tubule function. Skin and lung nodule biopsies revealed noncaseous granuloma. A biopsy of the salivary gland revealed focal lymphocyte infiltration. Criteria for classification Based on clinical and laboratory findings, this patient met the criteria for sarcoidosis and Sjogren's syndrome. This case adds to our understanding of Sjogren's syndrome and sarcoidosis overlap and provides a reference value for clinical diagnosis.

Skincare products play a pivotal part in precluding the dry skin convinced by colorful causes. Certain constituents can help to ameliorate the efficacity of skincare products. Galactomyces raise filtrate (GFF) is such a functional component. Its use began from the empirical observation that the hands of sake spirits who deal with incentive turmoil retain a beautiful and immature appearance. Accordingly, skincare products grounded on GFF are extensively used throughout the world. Recent studies have demonstrated that GFF activates an aryl hydrocarbon receptor (AHR) and upregulates the expression of filaggrin, a vital endogenous source of natural moisturizing factors, in epidermal keratinocytes. It also activates nuclear factor erythroid-2-related factor 2 (NRF2), the antioxidative master recap factor, and exhibits potent antioxidative exertion against oxidative stress convinced by ultraviolet irradiation and proinflammatory cytokines, which also accelerate inflammaging. GFF- intermediated NRF2 activation downregulates the expression of CDKN2A, which is known to be overexpressed in ancient keratinocytes. also, GFF enhances epidermal terminal isolation by upregulating the expression of caspase- 14, claudin- 1, and claudin- 4. It also promotes the conflation of the antiinflammatory cytokine IL- 37 and downregulates the expression of proallergic cytokine IL- 33 in keratinocytes. In addition, GFF downregulates the expression of the CXCL14 and IL6R genes, which are involved in inflammaging. These salutary parcels might bolster the potent hedge- guarding andantiinflammaging goods of GFF- containing skin formulae.