Normal functioning of Gastric epithelial cells needs continuous check over multiple signaling pathways. Dysrhythmic behavior of any of the pathways at any of the steps can lead to unleashing of devastating effects. Tracking these abnormal steps can be a way forward for controlling the aggressiveness of these cells. Here in this review we have summed up various studies in order to link different hierarchies of the key pathway leading to gastric cancer. Out of all, JAK/STAT pathway is considered to be a master regulator for cell signaling. Abnormal functioning of JAK/STAT pathway at any of the steps ranging from inflammation caused by Helicobacter pylori to its negative regulator SOCS-1 can bring about the devastating nature of this pathway which ultimately leads Gastric Carcinoma. However in this review we have tried to track different steps of this pathway to find out the possible means of impeding the aggressiveness caused due to any abnormality.
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Journal of Immunobiology received 34 citations as per Google Scholar report
