Study Of Magentic Properties Of Fe-Al Intermetallic Compound

2^nd International Conference and Exhibition on Materials Science & Engineering

October 07-09, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

Aniket Annasaheb Maske

Accepted Abstracts: J Material Sci

Abstract :

The main goal of the current work is to develop an in situ thermo-gelling composite system for intra articular delivery of drugs for OA. The composite in situ thermo-gelling chitosan system (CIG) comprises of Etoricoxib loaded PCL (Poly Caprolactone) microparticles embedded in an in situ forming chitosan gel, which gels at physiological temperature (37 °C). Etoricoxib loaded PCL microparticles is prepared by Oil/Water (O/W) emulsion solvent evaporation method. In situ chitosan thermogelling system is prepared by mixing 1.6% chitosan solution with 60% ammonium hydrogen phosphate (AHP) followed by incubation at 37 °C. The composite in situ gels (CIG) is prepared by dispersing PCL microparticles in the chitosan-AHP solution and incubated at 37 °C.The particles are found to be smooth and spherical using SEM. FTIR studies confirms the absence of any chemical interaction between PCL and Etoricoxib. The drug loading and entrapment efficiency are also determined. An in-vitro drug release study at pH 7.4 by dialysis-membrane method shows controlled release for around 20 days. Gellation time of CIG is determined to be 11 minutes. The drug is released in a much more controlled manner for CIG than PCL microparticles alone. The biocompatibility of the system is confirmed by performing in vitro cytotoxicity studies using MTT Assay in L929 cell lines. Thus to conclude, this novel composite in situ system can be a good, non-invasive intra-articular drug delivery system for the controlled delivery of drugs and proteins to the diseased joints.

Biography :

Arunkumar P. is currently pursuing Ph.D. in centre for research in nanotechnology and science, IIT Bombay, Mumbai. He completed his masters in nanomedical sciences at Amrita Centre for Nanosciences and Molecular Medicine, Cochin. He has a proceeding publication titled ?Efficient delivery system of nano silymarin to the prostate cancer cells? in the conference ?Emerging trends in biotechnology 2012? organized by CUSAT, Cochin, India.