Polymer microarrays-Fabrication and biological application for cellular control and manipulation

2^nd International Conference and Exhibition on Materials Science & Engineering

October 07-09, 2013 Hampton Inn Tropicana, Las Vegas, NV, USA

Mark Bradley

Accepted Abstracts: J Material Sci

Abstract :

Iwill demonstrate a variety of approaches for the preparation and high-content screening of polymer microarray platform and their application in a number of cell based screens. Fabrication methods, including direct inkjet based polymer synthesis and analysis with fixed and live cells on over 10,000 features will be described. Using polymer technology, I will show how polymers have been identified and then developed for a myriad of applications, including control of stem cells fate, corneal bandages, bacterial capture and thermally responsive surfaces. This includes: 1. Polymer blends that can find use as implants which support cell attachment, growth and differentiation, and tissue regeneration in vivo and can be used in bone repair. This has led, for example, to polymers that are able to bind Sto+ cells and promote bone regeneration with materials now entering large animal models the first step on the road to human application 2. Polymers able to support long term highly functional hESC-derived hepatocyte like cells (showing high levels of both CYP3A4 and CYP1A2 expression) and which are now being explored as a coating on an extra-corporeal support for trials in bio-artificial liver devices 3. Polymers displaying binding or inhibition of binding of bacteria 4. Polymers that bind human stem cells, maintain them in a highly controlled state, yet allow mild thermal release, while maintaining full pluripotency.

Biography :

Dalia Saad has obtained her Ph.D. very recent (Sep 2013) from Wits University, South Africa where she obtained her MSc (with distinction) in Environmental Chemistry (2011). Her research interest is on water pollution issues and promoting access to clean healthy water. Her work involves theoretical as well as application aspects (e.g. commercialization, environmental impact and cost-effectiveness). Dalia has presented her work in local and international conferences; she has also published several articles in reputed journals. Dalia is a member of numerous professional bodies including: Golden Key international honor society (GKIHS), Young Water Professionals (YWPs), Water institute of South African (WISA), South African Chemical institute (SACI), International Association for Impact Assessment South Africa Affiliate (IAIA), and Third World Organization for Women in Science (TWOWS).