Nanoparticle-based colloidal delivery systems: Thermosensitive hydrogels containing self-assembled micelles

3^rd International Conference and Exhibition on Materials Science & Engineering

October 06-08, 2014 Hilton San Antonio Airport, USA

Mohammad Nasri

Accepted Abstracts: Material Sci Eng

Abstract :

Advanced drug delivery and targeting has seen spectacular achievements over recent years to overcome many obstacles in the way of timing and targeting the delivery to fulfill therapeutic potentiality of chemicals. The purpose of this investigation was to prepare and characterize novel polymeric nanoparticle-based products aimed at using for rate-controlled release, prolonged/sustained release, and targeted/spatial drug delivery systems. The products were formulated with sodium carboxymethylcellulose (NaCMC), some types of polysorbates, and glycerol. The synthesis process was performed by heating/ cooling method, as a type of physical cross-linking method for producing hydrogel, in three steps to optimize physical and chemical characteristics. A series of nanoparticle-based colloidal products as liquid suspensions were developed, and from all three steps, about forty types were selected and investigated rheologically by bench-top experiments. Afterwards, two samples of product type III10 underwent a freeze-thawing method for five and one repeated cycles sequentially. Test tube inversion method was carried out on all the produced gels. Most of the products were new types of temperature-sensitive, smart, physically self-assembled hydrogels and took the forms of sol, gel (opaque and transparent), and precipitate. However, these hydrogels showed opposite gelation property to customary temperature-sensitive gels. The product of five repeated freezingthawing cycles was also thermoreversible gel with a high mechanical stability and swelling capacity, as opposed to the product of one cycle. Some types of produced hydrogels behaved like a ternary system. These intelligent hydrogels take the major advantage of gelation property of NaCMC and micelle formation of polysorbates.

Biography :

Mohammad Nasri completed his Medical Doctorate (MD) in a seven years and a half course of study from Kerman University of Medical Sciences, Kerman, Iran. He has been involved as an interdisciplinary researcher in some multidisciplinary research topics in this university during the past years. His main field of research has been on Biomedical engineering, Drug delivery and transport, Novel routes of delivery, Delivery via the mucosal routes, Targeting and optimizing pulmonary delivery, Pharmaceutical sciences, and Rheology. He has conducted a group of original researches on a novel group of polymer-based colloidal drug delivery and release systems.