Morphogenic mussel inspired self-construction of versatile enzymatic biosensors by electrochemistry

Journal of Material Sciences & Engineering

ISSN: 2169-0022

Open Access

Morphogenic mussel inspired self-construction of versatile enzymatic biosensors by electrochemistry

16th International Conference on Emerging Materials and Nanotechnology

March 22-23, 2018 | London, UK

Janwa El-Maiss, Pierre Schaaf, Loic Jierry and Fouzia Boulmedais

Universite de Strasbourg, France

Scientific Tracks Abstracts: J Material Sci Eng

Abstract :

Biosensors have been widely applied due to their high sensitivity, potential selectivity, in addition to the possibility of miniaturization/ automation. Enzyme immobilization is a critical process in biosensors development with the necessity to avoid their denaturation and ensure their accessibility towards the analyte Among all of the enzymes applied in these biosensors, GOx is the most common one owing its importance for detection of blood glucose and its effectiveness in the diagnostic analysis of diabetes. Electrodeposition of macromolecules is increasingly considered to be the most suitable method for the design of biosensors. Here, we present for the first time the elaboration of a mussel-inspired versatile biosensor using a ?¢????One Pot?¢??? electrochemical morphogenic approach leading to a covalently cross-linked matrix of biscatechol and glucose oxidase with no leaking observed. The immobilized GOX in the film shows an electrochemical response to glucose using ferrocene methanol as free mediator in solution and has a wide linear range from 1 to 12.5 mM as well as a good sensitivity and affinity to glucose. All these advantageous features allow the development of miniaturized biosensors through functionalization of a single electrode out of a microelectrode array.

Biography :

Education: Lebanese University, Lebanon, B.S Chemistry; Claude Bernard University, France, M.S Organic Chemistry and synthesis of bioactive molecules; University of Nice Sophia-Antipolis, PhD Material chemistry and surface functionalization, Advisor: Prof. Frederic Guittard. Current position; Postdoctoral fellow a University of Strasbourg, Charles Sadron Institute. My early research involved synthesis of the natural product “Rhoptelol B”. During the course of my Ph.D, I was interested in low surface energy materials and their applications in both solid and liquid interface affording to superhydrophobic surfaces and non-bio accumulated surfactants. I am currently working to develop a new glucose biosensor elaborated by crosslinking the active enzyme covalently in the matrix.

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