Fungal-mediated structural transformation of contraceptive drugs, drospirenone and etonogestrel into new metabolites

Joint Event on 3^rd World Chemistry Conference & World Congress on Biotherapeutics and Bioanalytical Techniques

September 11-12, 2017 Dallas, USA

Elias Baydoun, Sheeza Iqbal, Nayab Shoaib, Atia-tul-Wahab, Colin Smith and M Iqbal Choudhary

American University of Beirut, Lebanon
University of Karachi, Pakistan

Scientific Tracks Abstracts: Chem Sci J

Abstract :

Biotransformation is an efficient approach for structural alteration of all classes of organic compounds. This technique is effectively employed in green chemistry, particularly in drug discovery and development, as it involves a variety of enzymes during transformation which results in regio-, chemo-, and stereo-selective products. In the current study, biotransformation of an orally active contraceptive drugs, drospirenone and etonogestrel was carried out at pH 7.0 and 26�±2�°C. Transformation of drospirenone with Cunninghamella elegans resulted in four new metabolites, 14�±-hydroxy-drospirenone, 11-oxodrospirenone, 12-oxo-drospirenone and 11�², 14�±-dihydroxy-drospirenone, along with a known metabolite and 11�±-hydroxydrospirenone. While transformation of etonogestrel with Cunninghamella blakesleeana and C. echinulata yielded three new metabolites 6�²-hydroxy-11, 22-epoxy-etonogestrel, 11, 22-epoxy-etonogestrel, 10�²-hydroxy-etonogestrel, along with two known metabolites 6�²-hydroxy-etonogestrel, and 14�±-hydroxy-etonogestrel.

Biography :

Elias Baydoun has completed his PhD at University of Cambridge, UK in the year of 1980. He is working as Professor at American University of Beirut, Lebanon. His research interests are membrane fusion in vitro, plant cell wall biosynthesis and assembly and biologically active oligosaccharides.
Email:eliasbay@aub.edu.lb