Development of mesoporous bioactive glass for in vitro tissue regeneration, drug release studies, cell cycle analysis and in vivo compatibility

6^th International Conference and Exhibition on Materials Science and Engineering

September 12-14, 2016 Atlanta, USA

Muhammad Shoaib, Aamer Saeed, Javeed Akhtar, Muhammad Saif ur Rahman and Muhammad Moazzam Naseer

Quaid-I-Azam University, Pakistan
COMSATS Institute of Information Technology, Pakistan
Zhejiang University School of Medicine, P.R. China

Posters & Accepted Abstracts: J Material Sci Eng

Abstract :

In recent years bioglass have gained popularity due to its excellent bioactivity and biocompatibility. Bioactive glass when implanted in body, bonds with living tissues directly. They have shown to enhance bone cell responses such as cell proliferation, cell adhesion, calcium deposition and alkaline phosphatase activity. Porous bioactive glass exhibit much enhanced biocompatibility and bioactivity due to greater specific surface area and pore volume. This study was aimed to synthesize a novel, more effective bioactive and biocompatible bioglass. In this work we report synthesis of mesoporous bioglass (MBG) by using facile sol-gel method. Polyethylene glycol (PEG 6000) was used as a soft template. The as-synthesized MBG samples were characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), Energy dispersive X-ray spectroscopy (EDX) and Brunauer Emmett Teller (BET). The as-prepared samples had spherical morphology as confirmed by SEM with size 1�¼m�±0.2. Furthermore, these samples were evaluated for cell proliferation, protein adsorption studies, cell cycle analysis and drug release studies. They showed better biocompatibility as confirmed by the formation of hydroxyapatite (Hap) layer on glass surface when soaked in simulated body fluid (SBF). MBG caused no inflammation during in vivo insertion and remained non-cytotoxic to normal cells. Drug loaded MBG showed a sustained release for more than two weeks.

Biography :

Email: relyables@gmail.com