Combined use of topical imiquimod and 5-fluorouracil in the management of in-transit cutaneous melanoma: A Case Report and Literature Review

15^th World Conference on Cosmetic Dermatology & Skin Diseases

September 25-26, 2019 | Lisbon, Portugal

Sheida Naderi-Azad, Marisa Ponzo

University of Toronto Medical School, Canada
University of British Columbia Faculty of Medicine, Canada

Posters & Accepted Abstracts: J Cosmo Trichol

Abstract :

Statement of the Problem: While there are numerous therapeutic options available for in-transit cutaneous melanoma, the treatments are often unsuccessful due to suboptimal response rates. This motivates the use of combination therapies such as imiquimod and 5-fluorouracil to increase therapeutic efficacy. Imiquimod and 5-fluorouracil have distinct mechanisms of action, with imiquimod binding to toll-like receptor 7 and 8 on leukocytes and 5-FU inhibiting thymidylate synthase and inhibiting DNA synthesis. The purpose of this case report is to describe the course of an 87-year-old female with an 8-year history of cutaneous melanoma. Findings: The patient was initially managed with a wide local excision of the right shin lesion, as well as a split-thickness graft. She was further treated with a combination of 5% topical imiquimod cream and 5% 5-fluorouracil cream. There was complete clearance within 23 months, and the patient has been diseasefree since. Conclusion & Significance: Given the patientâ??s complete clearance and disease-free state since treatment, we postulate that imiquimod and 5-FU’s synergistic mechanisms of action provide a valuable potential for targeting in-transit cutaneous melanoma in patients.