Characterization of bis(indolyl) methane dye loaded human and bovine serum albumins immobilized magnetic nanoparticles for drug delivery systems

6^th International Conference and Exhibition on Materials Science and Chemistry

May 17-18, 2018 | Rome, Italy

Roghaye Firouzi, Hamid Dezhampanah and Masoumeh Esmaili

University of Guilan, Iran

Posters & Accepted Abstracts: J Material Sci Eng

Abstract :

Bis(indolyl) methane (BIM) as one of the main active components of anticancer and antibacterial drugs is applied in medicinal and extensive area of chemistry. In this research, BIM is loaded on the human and bovine serum albumins immobilized magnetic nanoparticles surface for using in drug delivery systems. Superparamagnetic iron oxide nanoparticles (SPIONs) were prepared by co-precipitation method and then modified with [3-aminopropyl] tri-ethoxysilane (APTES) and then activated with 2,4,6-trichloro-1,3,5-triazine (TCT), covalently immobilized with human and bovine serum albumins and then BIM was interacted with immobilized serum albumins. UV-vis spectroscopy was used to estimate the binding capacity of serum albumins with modified superparamagnetic iron oxide nanoparticles (SPIONs) and the BIM with albumin coated modified SPIONs. The structure and composition of synthesized nanoparticles were examined by x-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential, and vibrating sample magnetometer (VSM) analyses. Cell culture study was carried out in MCF-7 cell line (human breast adenocarcinoma cell line).

Biography :

Roghaye Firouzi has PhD in Physical Chemistry from University of Guilan. She has published more than 7 papers in reputed journals and several publications in congresses.
Email:Roghaye_Firouzi@phd.guilan.ac.ir