γ-Fe2O3 superparamagnetic nanoparticles and their applications

3^rd International Conference and Exhibition on Materials Science & Engineering

October 06-08, 2014 Hilton San Antonio Airport, USA

Yan Minhao

Accepted Abstracts: Material Sci Eng

Abstract :

Recently, large research efforts were focused on the fabrication of inorganic nanoparticles (NPs) and their application in biomedical field. One of the promising biomedical applications of these NPs is their use as agents for tumor hyperthermia. Here, we interested in the fabrication of biofunctionalized NPs γ-Fe2O3 for hyperthermia. First, we developed simple protocols for coating nanoparticles by polyelectrolytes (PEs). We then evaluated the stability of these colloidal dispersions in various environments. Then we covalently grafted bioactive peptides to the coating layer of the NPs. These bioactive peptides can target to the specific receptors expressed on the surface of human prostate cancer cells. Local heating induced by applying a rotating magnetic field with high frequency can destroy the tumor tissue. Moreover, these NPs are also used as building blocks of supra-colloidal structures. In this approach, it is as if the NPs were ?atoms? and supra-colloidal objects were ?molecules? made from these ?atoms?. We developed an original approach based on the electrostatic complexation between the anionic superparamagnetic NPs with cationic PEs to obtain nanostructured cylindrical aggregates. These rigid wires remained superparamagnetic properties. The co-assemblage between these two species with opposite charges was controlled by a desalting method and extra charges repulsion. Using this method, we can easily control the length, mechanical rigidity and surface charges of these wires. Beyond, we show that this soft-chemistry assembly approach is a general phenomenon independent of the feature of the macromolecular building blocks, opening significant perspectives for the design of multifunctional materials.

Biography :

Yan Minhao has completed his PhD from Université du Maine/CNRS (France) and Postdoctoral studies from Université Paris-Diderot/CNRS (France). He was then employed as Researcher with manager status by Nanoscience Foundation, based in the French Alternative Energies and Atomic Energy Commission (CEA France). Afterwards he won the ?100 talent? project (Sichuan, China) in 2012. Actually he is the Distinguished Professor in State Key Laboratory Cultivation Base for Nonmetal Composites and Functional Materials, Southwest University of Science and Technology (SWUST). He has published more than 20 papers in reputed journals (ACS Nano, ACS Applied Materials & Interfaces, Soft Matter, etc).