Lipid-based Delivery of Essential Oils: Expanding Antimicrobial Applications through Nanotechnology

Elga Paola^*
*Correspondence: Elga Paola, Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, USA, Email:

Introduction

The rapid rise in antimicrobial resistance and the limitations of conventional antibiotics have driven a global push for innovative solutions in infection control and microbial management. Among the many alternatives being explored, essential oils have gained significant attention due to their potent and broad-spectrum antimicrobial properties. Derived from plants, essential oils such as those from tea tree, thyme, clove, and eucalyptus exhibit notable activity against bacteria, fungi, and even some viruses. However, despite their natural efficacy, essential oils face several challenges that limit their direct therapeutic and industrial application. Their volatility, instability under environmental conditions, poor solubility in aqueous media, and potential for irritation or toxicity at higher concentrations present hurdles for practical use. To overcome these limitations, researchers have increasingly turned to nanotechnologyâ??specifically lipid-based nanocarriersâ??as a means of enhancing the delivery, stability, and efficacy of essential oils in antimicrobial applications [1].

Description

Lipid nanoparticles, including Solid Lipid Nanoparticles (SLNs), Nanostructured Lipid Carriers (NLCs), and liposomes, represent a promising class of drug delivery systems due to their biocompatibility, biodegradability, and ability to encapsulate both hydrophilic and lipophilic substances. These nanocarriers can protect essential oils from environmental degradation, control their release over time, enhance their bioavailability, and reduce side effects by targeting delivery to specific sites. The nanoscale size of these carriers also facilitates better penetration into microbial cells and biofilms, potentially increasing antimicrobial efficacy even at lower concentrations. This combination of benefits makes lipid-based nanoparticles a particularly attractive platform for leveraging the therapeutic potential of essential oils in a wide range of applications, from pharmaceuticals and cosmetics to food preservation and agriculture. Recent advances in formulation science have led to the successful encapsulation of a variety of essential oils into different lipid nanoparticle systems. These systems rely on a solid lipid core stabilized by surfactants, offering structural rigidity and prolonged release profiles. However, because of their crystalline nature, SLNs may suffer from limited loading capacity and potential expulsion of the active compound over time [2].

To address this issue, nanostructured lipid carriers have been developed as a second-generation lipid system, incorporating both solid and liquid lipids into the core matrix. This creates a more disordered internal structure that allows higher payloads of essential oils and reduces the risk of leakage or degradation. Liposomes, composed of one or more phospholipid bilayers surrounding an aqueous core, offer yet another versatile method of essential oil encapsulation. They mimic biological membranes, allowing for improved interaction with microbial cells and enhanced penetration into tissues. Studies have shown that liposome-encapsulated essential oils can demonstrate superior antimicrobial effects compared to free oils, owing to their ability to concentrate the active components at the site of infection and maintain therapeutic levels over extended periods. Furthermore, liposomal formulations can be modified with surface ligands to achieve targeted delivery, opening new possibilities for precision antimicrobial therapy. In addition to enhancing therapeutic outcomes, lipid nanoparticles can mitigate some of the adverse effects associated with the direct use of essential oils. For instance, some essential oils are known to cause skin irritation or allergic reactions when applied topically at high concentrations [3].

By incorporating these oils into lipid-based carriers, their release can be modulated and their local concentration controlled, reducing the risk of toxicity while preserving antimicrobial activity. This feature is particularly beneficial in dermatological applications, where essential oil-loaded nanoparticles have been used to treat infections such as acne, fungal skin diseases, and wounds with minimal side effects. The incorporation of essential oils into lipid nanoparticles also offers significant advantages in non-pharmaceutical domains. In food preservation, where the demand for natural and safe antimicrobial agents is growing, nanoencapsulated essential oils have been used to inhibit the growth of foodborne pathogens and spoilage microorganisms. These systems can be applied directly to food products or incorporated into packaging materials to provide sustained antimicrobial protection. For instance, lipid nanoparticles carrying clove or cinnamon essential oil have been used to extend the shelf life of perishable items such as meat and dairy products. The encapsulation process not only protects the volatile compounds from degradation but also masks strong odors and tastes, making the essential oils more acceptable for consumer use. In agriculture, essential oil-loaded lipid nanoparticles have been explored as eco-friendly alternatives to chemical pesticides and fungicides [4].

These formulations can effectively target plant pathogens while minimizing harm to beneficial organisms and reducing environmental impact. Additionally, the controlled release properties of lipid nanoparticles reduce the frequency of application, lowering costs and labor requirements for farmers. Some studies have demonstrated that nanoencapsulated essential oils can enhance seed germination, plant growth, and resistance to disease, indicating a promising role in sustainable agriculture and crop protection. Despite these advantages, the development and commercialization of lipid-based essential oil delivery systems are not without challenges. One of the primary technical barriers is the complexity of formulation, as the physicochemical properties of essential oils such as volatility, hydrophobicity, and chemical instability must be carefully matched with the composition and structure of the lipid carrier. Surfactant selection, lipid type, and processing method all influence particle size, encapsulation efficiency, and release kinetics, requiring precise optimization. Furthermore, scalability and reproducibility remain concerns for industrial production. Advanced manufacturing techniques, such as high-pressure homogenization, microfluidization, and solvent evaporation, are being refined to produce nanoparticles with consistent quality at commercial scales [5].

Conclsuion

In conclusion, lipid-based nanoparticles present a powerful platform for enhancing the antimicrobial efficacy, stability, and usability of essential oils across diverse fields. By addressing the inherent limitations of essential oils and leveraging the advantages of nanotechnology, these systems offer a viable path forward in the development of safe, effective, and sustainable antimicrobial agents. Continued innovation in formulation techniques, regulatory clarity, and interdisciplinary collaboration will be critical to realizing the full potential of this promising area. Whether in medicine, food safety, agriculture, or consumer products, the fusion of lipid nanocarriers and essential oils stands poised to make a meaningful impact on global health and well-being.

Acknowledgement

None.

Conflict of Interest

None.

References

1. Thiruvengadam, Muthu, Hsiao-Yun Chi and Seon-Hwa Kim. "Impact of nanopollution on plant growth, photosynthesis, toxicity and metabolism in the agricultural sector: An updated review." Plant Physiol Biochem 207 (2024): 108370–108370.

Google Scholar Cross Ref Indexed at

2. Guidotti-Takeuchi, Mariana, Lucas N. de Morais Ribeiro and Felipe A.L. dos Santos, et al. "Essential oil-based nanoparticles as antimicrobial agents in the food industry." Microorganisms 10 (2022): 1504–1504.

Google Scholar Cross Ref Indexed at

3. Radwan, Inas T., Maha M. Baz, Hanan Khater and Ahmed M. Selim. "Nanostructured lipid carriers (NLC) for biologically active green tea and fennel natural oils delivery: Larvicidal and adulticidal activities against Culex pipiens." Molecules 27 (2022): 1939–1939.

Google Scholar Cross Ref Indexed at

4. de Araújo, Daniela R., Lucas N. de Morais Ribeiro and Eliana de Paula. "Lipid-based carriers for the delivery of local anesthetics." Expert Opin Drug Deliv 16 (2019): 701–714.

Google Scholar Cross Ref Indexed at

5. Pavoni, Laura, Daniele R. Perinelli, Giulia Bonacucina and Michele Cespi, et al. "An overview of micro- and nanoemulsions as vehicles for essential oils: Formulation, preparation and stability." Nanomaterials 10 (2020): 135–135.

Google Scholar Cross Ref Indexed at