Shariq Ahmad Wani*, Mohammed Sharfraz Ahamed, Shruthi Jayaram, and Shariq R. Masoodi
Sodium glucose co-transporter-2 inhibitors are associated with a range of adverse effects including Diabetic ketoacidosis both euglycemic and Hyperglycemic. However, this case report highlights a rare case of DKA/HHS overlap in a patient who was treated with SGLT2i. Most patients recover with prompt recognition and treatment, patient education about identifying early signs remains a cornerstone of early identification and treatment.
Carlos Mendoza
Fatima Zahra
Erik Johansson
Amara Okafor
Sofia Petrova
Chen Yung
Amanda Castro de Bone*, Ana Elisa Altoé Matielo, Debora Rocha Barboza de Azevedo, Júlia Gava Tolentino, Ramona Dutra Uliana and Antônio Chambô Filho
DOI: 10.37421/2684-4915.2026.10.423
Introduction: Fournier’s gangrene is a severe necrotizing infection involving the perineal and genital tissues. In women, comorbidities such as Diabetes Mellitus (DM) increase susceptibility to this infection and worsen clinical progression. This study aims to report a case series of Fournier’s gangrene in female patients with a prior diagnosis of DM, analyzing the influence of diabetic pathophysiology on disease severity, clinical course, and outcomes. Methods: This observational descriptive study was conducted as a case series. Data were collected after approval by the Research Ethics Committee and following the acquisition of written informed consent from all patients. Results: Three female patients with type 2 DM and inappropriate glycemic control were included. All patients initially presented with severe perineal pain, cardinal signs of inflammation, and foul-smelling purulent discharge, with rapid progression to necrotizing infection. Management included hospitalization, intravenous antibiotic therapy, and multiple surgical debridements, with microbiological cultures guiding treatment. After clinical stabilization, glycemic control, and improvement of lesions, all patients underwent surgical wound closure and were subsequently discharged with multidisciplinary outpatient follow-up. Conclusion: Diabetic patients present a higher risk and greater severity of Fournier’s gangrene, requiring early diagnosis, aggressive management, broad-spectrum antibiotic therapy, repeated debridements, and strict glycemic control to reduce complications and mortality. Furthermore, a structured discharge plan with multidisciplinary follow-up and optimized metabolic management is essential to prevent recurrence and improve prognosis.
Clinical and Medical Case Reports received 53 citations as per Google Scholar report
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